Hypolipidemic activity of phthalimide derivatives V: Reduced and hydrolytic products of simple cyclic imides.
Hypolipidemic activity of phthalimide derivatives V: Reduced and hydrolytic products of simple cyclic imides.
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邻苯二甲酰亚胺衍生物V的降血脂活性：简单环状酰亚胺的还原和水解产物。
DOI：
10.1002/jps.2600731041
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发表时间：
1984
影响因子：
3.8
通讯作者：
Hall,IH
中科院分区：
文献类型：
--
作者：
ChapmanJr,JM;Wyrick,SD;JoséeVoorstad,P;Maguire,JH;Cocolas,GH;Hall,IH
一系列环状酰亚胺和相关化合物先前已被证明在20 mg/kg/d的低剂量水平下具有降血脂活性。水解和还原产物的环状酰亚胺的合成和检查，以辨别是否可能的代谢产物是这些降血脂剂的活性化学物质。邻苯二甲酰亚胺被证明是最活跃的环状酰亚胺测试。不幸的是，这些新产品一般来说并没有改善啮齿动物的降血脂活性。例外的是哌啶，其表现出改善的降胆固醇活性，以及3，4，5，6-二苯并高哌啶-2-酮，其表现出与邻苯二甲酰亚胺相比改善的降胆固醇活性。
A series of cyclic imides and related compounds have previously been shown to possess hypolipidemic activity at the low dose level of 20 mg/kg/d. Hydrolytic and reduced products of the cyclic imides were synthesized and examined to discern if possible metabolic products were the active chemical species of these hypolipidemic agents. Phthalimide proved to be the most active cyclic imide tested. Unfortunately, the new products did not, in general, improve hypolipidemic activity in rodents. The exceptions were piperidine which demonstrated improved hypotriglyceridemic activity, and 3,4,5,6‐dibenzohomopiperidin‐2‐one, which demonstrated improved hypocholesterolemic activity compared to phthalimide.