Static control logic for microfluidic devices using pressure-gain valves
Static control logic for microfluidic devices using pressure-gain valves
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DOI：
10.1038/nphys1513
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发表时间：
2010-03-01
期刊：
影响因子：
19.6
通讯作者：
Horowitz, Mark A.
中科院分区：
文献类型：
--
作者：
Weaver, James A.;Melin, Jessica;Horowitz, Mark A.
近年来，微流控技术得到了很大的发展，使得多个分析系统可以放在一个微流控芯片上。然而，像微电子工业那样实现控制元件的微流控大规模集成仍然是一个挑战。我们提出了一种集成的微流体阀，与标准的软光刻工艺兼容，其压力增益远大于统一。我们表明，这使得完全静态的数字控制逻辑和状态存储直接集成在芯片上，最终使微流体状态机的设计成为可能。该数字控制逻辑的输出可用于控制传统的分析物流量阀。这一策略使得目前实验室中用于控制气动驱动微流控芯片的大量笨重的外部硬件转移到微流控芯片上，从而大大减少了外部芯片连接所需的数量。
Microfluidic technology has developed greatly in recent years, enabling multiple analysis systems to be placed on a microfluidic chip. However, microfluidic large-scale integration of control elements analogous to those achieved in the microelectronics industry is still a challenge. We present an integrated microfluidic valve, compatible with standard soft-lithography processes, which has a pressure gain much greater than unity. We show that this enables integration of fully static digital control logic and state storage directly on-chip, ultimately enabling microfluidic-state machines to be designed. Outputs from this digital control logic can then be used to control traditional analyte flow valves. This strategy enables much of the bulky external hardware at present used to control pneumatically driven microfluidic chips in the laboratory to be transferred onto the microfluidic chip, which drastically reduces the required number of external chip connections.