ON THE ORIGIN AND PROGRESSION OF HUMAN-BREAST CANCER
ON THE ORIGIN AND PROGRESSION OF HUMAN-BREAST CANCER
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DOI：
10.1016/0002-9378(86)90713-1
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发表时间：
1986-06-01
影响因子：
9.8
通讯作者：
JENSEN, HM
中科院分区：
文献类型：
--
作者：
JENSEN, HM
成熟的人类女性乳房包含数千个对乳房敏感的、潜在的产奶微器官，称为小叶。在非妊娠状态下，它们的大小从1到8 mm不等，但大多数直径为1到2 mm。每个小叶都有一个与主导管系统相连的终末导管排出。它被称为终末导管小叶单位，通常在绝经期退化。除了大导管内的乳头状瘤外，大多数乳腺疾病都发生在终末导管小叶单位。疾病过程如增生和瘤形成改变终末导管小叶单位到这样一种程度，即常规光镜外观使结构看起来好像它们是导管。然而，三维的基本微结构被保留下来，证明癌症的起源是终末导管-小叶单位。
The mature human female breast contains thousands of hormone-sensitive, potentially milk-producing microorgans, called lobules. In the nonpregnant state they vary in size from 1 to 8 mm but most are 1 to 2 mm in diameter. Each lobule is drained by a terminal duct attached to the main duct system. It is called the terminal ductal-lobular unit, which normally regresses at menopause. Most breast diseases except papillomas in major ducts arise in terminal ductal-lobular units. Disease processes such as hyperplasias and neoplasia alter the terminal ductal-lobular units to such a degree that conventional light microscopic appearances make the structures appear as though they were ducts. However, the basic microarchitecture in three dimensions is preserved, proving the origin of cancer is the terminal ductal-lobular unit.