The role of hyaluronan in innate defense responses of the intestine.
The role of hyaluronan in innate defense responses of the intestine.
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DOI：
10.1155/2015/481301
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发表时间：
2015
影响因子：
--
通讯作者：
Kessler SP
中科院分区：
文献类型：
--
作者：
de la Motte CA;Kessler SP
海洛烷是脊椎动物肠道中普遍存在的丰富的细胞外基质组分。在这里，我们讨论了什么是已知的透明质酸分布在体内平衡和炎症性疾病的肠道和讨论的方式，这种糖胺聚糖可以参与调节先天宿主防御机制。这些自然反应包括在细菌攻击/结肠组织损伤后促进快速白细胞募集的机制以及促进肠中的上皮防御机制。
Hyaluronan is an abundant extracellular matrix component prevalent in the vertebrate intestinal tract. Here we discuss what is known about hyaluronan distribution during homeostasis and inflammatory diseases of the gut and discuss ways in which this glycosaminoglycan can participate in regulating innate host defense mechanisms. These natural responses include mechanisms promoting rapid leukocyte recruitment after bacterial challenge/colon tissue damage as well as promoting epithelial defense mechanisms in the intestine.