An open-label pilot study to assess the efficacy and safety of virgin coconut oil in reducing visceral adiposity.
An open-label pilot study to assess the efficacy and safety of virgin coconut oil in reducing visceral adiposity.
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DOI：
10.5402/2011/949686
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Rasool AH
中科院分区：
文献类型：
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作者：
Liau KM;Lee YY;Chen CK;Rasool AH
导论.这是一项开放标签的试点研究，为期四周的初榨椰子油（VCO），以研究其在20名肥胖但健康的马来志愿者中的减肥功效和使用安全性。方法论通过测量VCO摄入前一周和摄入后一周的体重和相关人体测量参数以及血脂谱来评估疗效。通过比较摄入VCO前一周和摄入VCO后一周的器官功能测试来评估安全性。配对t检验用于分析所有可测量变量的任何差异。结果仅腰围（WC）显著降低，平均降低2.86 cm或较初始测量值降低0.97%（P = 0.02）。仅在男性中观察到WC减少（P <0.05）。血脂谱无变化。肌酐和丙氨酸转移酶水平略有降低。结论VCO对于WC减少是有效的，尤其是在男性中，并且其用于人类是安全的。
Introduction. This is an open-label pilot study on four weeks of virgin coconut oil (VCO) to investigate its efficacy in weight reduction and its safety of use in 20 obese but healthy Malay volunteers. Methodology. Efficacy was assessed by measuring weight and associated anthropometric parameters and lipid profile one week before and one week after VCO intake. Safety was assessed by comparing organ function tests one week before and one week after intake of VCO. Paired t-test was used to analyse any differences in all the measurable variables. Results. Only waist circumference (WC) was significantly reduced with a mean reduction of 2.86 cm or 0.97% from initial measurement (P = .02). WC reduction was only seen in males (P < .05). There was no change in the lipid profile. There was a small reduction in creatinine and alanine transferase levels. Conclusion. VCO is efficacious for WC reduction especially in males and it is safe for use in humans.