Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face.
Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face.
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DOI：
10.1186/s13005-016-0106-0
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发表时间：
2016-02-05
影响因子：
3
通讯作者：
Lemmer J
中科院分区：
文献类型：
--
作者：
Feller L;Khammissa RAG;Kramer B;Altini M;Lemmer J
紫外线是皮肤基底细胞癌、皮肤鳞状细胞癌和皮肤黑色素瘤的重要危险因素。这些癌症最常影响那些皮肤白皙、眼睛蓝的人，他们被晒伤，而不是被晒黑。然而，这些癌症中的每一种似乎都与不同的紫外线暴露模式有关，并由不同的细胞内分子途径介导。一些黑素皮质素1受体(MC1R)基因变异体通过与调节免疫炎症反应、DNA修复或细胞凋亡的其他基因的相互作用，在皮肤基底细胞癌、皮肤鳞状细胞癌和皮肤黑色素瘤的发病机制中发挥直接作用，此外，它们还通过与调节免疫炎症反应、DNA修复或细胞凋亡的其他基因相互作用来决定易癌的色素表型(白皙皮肤、红发、蓝眼睛)。在这篇简短的综述中，我们重点讨论紫外线在皮肤基底细胞癌、皮肤鳞状细胞癌和皮肤黑色素瘤中的病因学作用，以及一些相关的生物病理学事件。
Ultraviolet light (UV) is an important risk factor for cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin. These cancers most commonly affect persons with fair skin and blue eyes who sunburn rather than suntan. However, each of these cancers appears to be associated with a different pattern of UV exposure and to be mediated by different intracellular molecular pathways. Some melanocortin 1 receptor (MC1R) gene variants play a direct role in the pathogenesis of cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma apart from their role in determining a cancer-prone pigmentory phenotype (fair skin, red hair, blue eyes) through their interactions with other genes regulating immuno-inflammatory responses, DNA repair or apoptosis. In this short review we focus on the aetiological role of UV in cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin, and on some associated biopathological events.