Effects of partial surgical pancreatectomy in rats. I. Pancreatic regeneration.
Effects of partial surgical pancreatectomy in rats. I. Pancreatic regeneration.
复制标题
部分手术胰腺切除术对大鼠的影响。
DOI：
10.1016/s0016-5085(77)80258-8
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发表时间：
1977
期刊：
影响因子：
29.4
通讯作者：
B. Torrance
中科院分区：
文献类型：
--
作者：
K. Pearson;D. Scott;B. Torrance
在手术切除50%、70%或90%的胰腺后，测定平均体重176 g的雄性Wistar大鼠的胰腺再生能力。在该体重的对照动物中，胰腺生长仍在发生，但在2个月后停止。在此期间，切除动物的残余胰腺的生长大于对照组，并且在切除50%、70%和90%后，残余胰腺的最终重量分别比假手术动物的相应节段的重量大21%、32%和78%。腺泡细胞的增殖测定放射自显影检测氚标记的胸苷掺入对照组和切除90%后。在实验的前2周，对照组动物的腺泡细胞增殖显著高于后来下降到非常低的水平。切除后2 ~ 5天，90%切除动物的增殖明显高于对照组，再加上此时发生的有限肥大，足以解释前2周残留胰腺重量的增加。我们无法解释对照组或切除组动物在2周至2个月之间胰腺重量的增加，无论是腺泡细胞肥大还是增生。
The capacity for pancreatic regeneration in male Wistar rats of average weight 176 g was determined after surgical resection of 50, 70, or 90% of the pancreas. In control animals of this weight pancreatic growth was still taking place but ceased after 2 months. Growth of the residual pancreas in resected animals over this period was greater than in controls and the final weight of the residual pancreas was 21, 32, and 78% greater than that of the corresponding segments in sham-operated animals after 50, 70, and 90% resection respectively. Proliferation of acinar cells was assayed by autoradiographic detection of tritiated thymidine incorporation in controls and after 90% resection. Proliferation of acinar cells in control animals during the first 2 weeks of the experiment was significantly higher than at later times when it fell to very low levels. Proliferation in 90% resected animals was markedly higher than in controls from 2 to 5 days after resection and, together with the limited hypertrophy occurring at this time, adequately accounted for the increase in weight of the residual pancreas during the first 2 weeks. We were unable to explain the increase in pancreatic weight in control or resected animals between 2 weeks and 2 months either in terms of hypertrophy or hyperplasia of acinar cells.