Modulation of the Na,K-ATPase by Ca and intracellular proteins.
Modulation of the Na,K-ATPase by Ca and intracellular proteins.
复制标题
Ca 和细胞内蛋白质对 Na,K-ATP 酶的调节。
DOI：
10.1146/annurev.ph.50.030188.001451
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发表时间：
1988
影响因子：
18.2
通讯作者：
Yingst,DR
中科院分区：
文献类型：
--
作者：
Yingst,DR
Na，K-ATP酶活性对CaI的生理变化敏感。细胞内的蛋白质，如钙调蛋白，钙调素，蛋白激酶C可以调节泵在Cai的瞬态变化。这些蛋白质与Na，K-ATP酶相互作用的机制、它们在不同种类细胞中的分布以及它们在调节Na，K-ATP酶中的作用尚未确定。初步数据表明，在生理范围内的Cai的增加可能与酶活性的刺激或抑制或哇巴因的Na，K-ATP酶的亲和力的变化。反应的类型可能取决于细胞的种类、其相关的细胞内蛋白质及其生理状态。Ca和胞内蛋白质在激素对Na，K-ATP酶的调节中起关键作用。
The activity of the Na, K-ATPase can be sensitive to physiological changes in Cai. Intracellular proteins such as calnaktin, calmodulin, and protein kinase C could regulate the pump during transient changes in Cai. The mechanisms by which these proteins interact with the Na, K-ATPase, their distribution in different kinds of cells, and their role in regulating the Na, K-ATPase are not yet determined. Preliminary data indicate that an increase in Cai within the physiological range could be associated with either a stimulation or an inhibition of enzyme activity or a change in the affinity of the Na, K-ATPase for ouabain. The type of response probably depends on the kind of cell, its associated intracellular proteins, and its physiological state. Ca and intracellular proteins could play a key role in the regulation of the Na, K-ATPase by hormones.