Skin necrosis following injection of non-steroidal anti-inflammatory drug
Skin necrosis following injection of non-steroidal anti-inflammatory drug
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DOI：
10.1093/bja/88.1.139
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发表时间：
2002-01-01
影响因子：
9.8
通讯作者：
Davison, PM
中科院分区：
文献类型：
--
作者：
McGee, AM;Davison, PM
我们报告了两名患者在大腿前外侧肌肉注射非甾体抗炎药后出现皮肤坏死。两名患者都需要进一步进行多次手术，其中一名患者出现危及生命的败血症。他们身上都留下了毁容的伤疤。皮肤坏死虽然罕见，但却是肌肉注射非甾体抗炎注射剂的一种公认的不良反应。很可能注射剂是在不知情的情况下进行皮下注射的。确保肌肉内给药并使用适当的针头长度非常重要。
We report two patients who developed skin necrosis following an intramuscular injection of non-steroidal anti-inflammatory drug into the anteriolateral area of their thigh. Both patients required further multiple operations and one developed life threatening, septicaemia. They were left with disfiguring scars. Skin necrosis, although rare, is a recognized adverse reaction to intramuscular non-steroidal anti-inflammatory injections., It is likely that the injections were, unwittingly, administered subcutaneously. It is important to ensure intra-muscular administration, with an appropriate needle length.