Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer.
Myofibroblasts of the muscle layer stimulate the malignant potential of colorectal cancer.
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DOI：
10.3892/or.2016.4932
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发表时间：
2016-09
期刊：
影响因子：
4.2
通讯作者：
Kijima H
中科院分区：
文献类型：
--
作者：
Takatsuna M;Morohashi S;Yoshizawa T;Hirai H;Haga T;Ota R;Wu Y;Morohashi H;Hakamada K;Terai S;Kijima H
结直肠癌（CRC）的肌成纤维细胞与淋巴结转移、肝转移和局部复发等组织病理因素有关。然而，很少有研究评估这些恶性潜能与CRC中肌成纤维细胞分布之间的关系。我们的目的是评估临床因素与CRC侵袭性病变周围肌成纤维细胞分布的关系。该研究包括121例诊断为II期或III期的pT3型CRC。测定粘膜下层（SM）、固有肌层（MP）和浆膜下层（SS）三个组织学层的肌成纤维细胞密度。通过对三层组织病理特征的研究，分析临床病理因素与肌成纤维细胞密度的关系。高频淋巴浸润组和静脉浸润组MP层肌成纤维细胞密度显著高于低频淋巴浸润组（P<0.001）和静脉浸润组（P<0.01）。淋巴结转移阳性组MP层肌成纤维细胞密度显著高于淋巴结转移阴性组（P<0.001）。MP层肌成纤维细胞密度高组总生存率较差（P<0.003）。我们的研究表明，肌成纤维细胞是一种与癌症相关的成纤维细胞，肌成纤维细胞的分布有助于CRC的恶性潜能。此外，我们证明MP层的肌成纤维细胞在CRC患者的恶性潜能和不良预后中发挥重要作用。
Myofibroblasts of colorectal cancer (CRC) have been associated with histopathological factors such as lymph node metastasis, liver metastasis and local recurrence. However, few studies have assessed the association between these malignant potentials and the myofibroblast distribution in CRC. We aimed to evaluate the relationship between clinical factors and myofibroblast distribution around CRC invasive lesions. The study included 121 cases of pT3 CRC that were diagnosed at stage II or III. Myofibroblast density of the following three histological layers was measured: the submucosa (SM), muscularis propria (MP) and subserosa (SS). We analyzed the relationship between the clinicopathological factors and myofibroblast density by studying the histopathological features of the three layers. The myofibroblast density of the MP layer was significantly higher in the groups with high-frequency lymphatic and venous invasion than the groups with low-frequency lymphatic (P<0.001) and venous (P<0.01) invasion, respectively. In the positive lymph node metastasis group, the myofibroblast density at the MP layer was significantly higher than that in the negative lymph node metastasis group (P<0.001). The high myofibroblast density group at the MP layer was significantly associated with poor overall survival (P<0.003). Our study indicated that myofibroblasts are a type of cancer-associated fibroblasts and that the myofibroblast distribution contributes to the malignant potential of CRC. Furthermore, we demonstrated that myofibroblasts present at the MP layer play an important role in the malignant potential and poor prognosis of patients with CRC.