Clinical implications of telomerase in cancer
Clinical implications of telomerase in cancer
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DOI：
10.1016/s0959-8049(97)00057-9
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发表时间：
1997-04-01
影响因子：
8.4
通讯作者：
Kim, NW
中科院分区：
文献类型：
--
作者：
Kim, NW
细胞永生被认为是肿瘤发生的关键步骤。作为端粒维持机制的重要组成部分，端粒酶的激活与细胞永生和癌症密切相关。端粒酶在大多数肿瘤中表达，但在大多数躯体组织中不表达，并与许多癌症类型的临床结果相关。端粒酶的表达与细胞分化程度有关，但与细胞增殖率无关。数据还表明，端粒酶的抑制或缺失可能导致癌细胞的细胞危机和癌症患者的肿瘤消退。这些结果表明，基于端粒酶抑制的肿瘤治疗可能是一种更有效、更安全的癌症治疗方法，并为癌症的诊断和预测临床结果提供了更准确的手段。通过精心设计的临床研究，全面了解端粒酶在肿瘤发生中的作用，将对癌症的治疗和诊断产生重大的临床影响。(C)1997年爱思唯尔科学有限公司。
Cellular immortality is believed to be a critical step in tumorigenesis. As an important component of the telomere maintenance mechanism, the activation of the enzyme telomerase is tightly associated with cellular immortality and cancer. Telomerase expression is detected in a majority of tumours, but is absent in most somatic tissues and correlates to clinical outcome in a number of cancer types. Telomerase expression is associated with the stage of differentiation but not necessarily with the rate of cell proliferation. Data also indicate that inhibition or absence of telomerase may result in cell crisis in cancer cells and tumour regression in cancer patients. These results suggest that cancer therapy based on telomerase inhibition could be a more effective and safer treatment for cancer, as well as provide a more accurate means for diagnosing and predicting clinical outcome in cancer. Complete understanding of the role of telomerase in tumorigenesis through well-designed clinical studies will have a significant clinical impact on the treatment and diagnosis of cancer. (C) 1997 Elsevier Science Ltd.