Effects and mechanisms of chinese herbal medicine in ameliorating myocardial ischemia-reperfusion injury.
Effects and mechanisms of chinese herbal medicine in ameliorating myocardial ischemia-reperfusion injury.
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DOI：
10.1155/2013/925625
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Fan D
中科院分区：
文献类型：
--
作者：
Liu Q;Li J;Wang J;Li J;Janicki JS;Fan D
心肌缺血再灌注(MIR)损伤是导致冠状动脉疾病发病率和死亡率的主要因素，仅在美国每年就有大约45万人死亡。中草药，尤其是中草药组方，在中医治疗心肌梗死中已有数百年的历史。虽然中草药的疗效得到了很好的证明，但其潜在的分子机制仍然难以捉摸。在这篇综述中，我们重点介绍了最近的研究，这些研究集中于在实验环境中使用提取物、单一草药或草药配方来阐明细胞和分子机制。这些研究代表了最近在心肌梗死治疗中弥合古代中草药之谜与现代细胞和分子生物学概念之间的差距的努力。
Myocardial ischemia-reperfusion (MIR) injury is a major contributor to the morbidity and mortality associated with coronary artery disease, which accounts for approximately 450,000 deaths a year in the United States alone. Chinese herbal medicine, especially combined herbal formulations, has been widely used in traditional Chinese medicine for the treatment of myocardial infarction for hundreds of years. While the efficacy of Chinese herbal medicine is well documented, the underlying molecular mechanisms remain elusive. In this review, we highlight recent studies which are focused on elucidating the cellular and molecular mechanisms using extracted compounds, single herbs, or herbal formulations in experimental settings. These studies represent recent efforts to bridge the gap between the enigma of ancient Chinese herbal medicine and the concepts of modern cell and molecular biology in the treatment of myocardial infarction.