Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma
Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma
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DOI：
10.1111/j.1600-0714.2007.00526.x
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发表时间：
2007-05-01
影响因子：
3.3
通讯作者：
Son, Hyun-Jin
中科院分区：
文献类型：
--
作者：
Cho, Nam-Pyo;Han, Hye-Suk;Son, Hyun-Jin
背景：环氧合酶（考克斯）-2在多种人类肿瘤中的过表达提示考克斯-2与肿瘤的发生有关。虽然考克斯-2的表达已被证明是上调的涎腺癌，其机制尚未完全理解。HuR是一种mRNA结合蛋白，控制考克斯-2等转录物的稳定性。方法：采用免疫组化法检测28例涎腺多形性腺瘤和18例涎腺粘液表皮样癌中考克斯-2和HuR的表达。35.7%的多形性腺瘤和72.2%的粘液表皮样癌的肿瘤细胞胞浆中检测到HuR。粘液表皮样癌中考克斯-2免疫反应性增高与胞浆HuR表达相关，而多形性腺瘤中则无相关性。结论：本研究提示，涎腺粘液表皮样癌中胞浆HuR与考克斯-2表达相关。此外，免疫反应性的考克斯-2和细胞质的HuR可能被用来评估的性质，一个交界性恶性肿瘤的唾液腺。
BACKGROUND: The overexpression of cyclooxygenase (COX)-2 in several human carcinomas suggests that COX-2 is related to carcinogenesis. Although COX-2 expression has been shown to be up-regulated in carcinomas of the salivary gland, its mechanisms are not completely understood. HuR is an mRNA-binding protein that controls the stability of certain transcripts including COX-2.METHODS: The expression of COX-2 and HuR was determined by immunohistochemistry in 28 cases of salivary pleomorphic adenoma and 18 cases of saliva mucoepidermoid carcinoma.RESULTS: 28.6% and 72.2% of the pleomorphic adenomas and mucoepidermoid carcinomas showed high COX-2 expression respectively. 35.7% of pleomorphic adenomas and 72.2% of mucoepidermoid carcinomas were tested positive for HuR in the cytoplasm of tumor cells. There was a correlation between a high COX-2 immunoreactivity and cytoplasmic HuR expression in mucoepidermoid carcinomas but not in pleomorphic adenomas.CONCLUSION: This study suggests that cytoplasmic HuR is correlated with COX-2 expression in salivary mucoepidermoid carcinomas. In addition, the immunoreactivity of COX-2 and cytoplasmic HuR might be used to evaluate the nature of a borderline malignancy in the salivary glands.