The phenomenon of chemo brain.
The phenomenon of chemo brain.
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DOI：
10.1188/05.cjon.713-721
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发表时间：
2005-12-01
影响因子：
1.1
通讯作者：
Segatore, Milena
中科院分区：
文献类型：
--
作者：
Staat, Kari;Segatore, Milena
化疗期间和化疗后，一些患者会出现记忆、注意力和认知功能其他方面的困难。这种一系列的缺陷通常被称为“化疗脑”。尽管这一现象尚未被完全理解，但随着癌症生存率的提高，它的意义越来越大。大多数幸存者的家庭、就业和学术活动预计会恢复到诊断前的水平。基础科学、影像学和临床科学的进步开始揭示病理生理机制并制定神经保护策略。药物选择借鉴了多种疾病，包括注意力缺陷/多动障碍和神经退行性疾病。传统疗法很快就会找到新的应用；例如，最近的临床前数据表明，促红细胞生成素可能具有一定的神经保护能力，这可能会对接受化疗的患者产生积极影响。一种协作模式将有兴趣解开这一现象之谜并制定管理策略以减轻其影响的国际专家聚集在一起。本文将回顾化疗脑的临床特征以及有关病理生理学的工作假设。将讨论肿瘤科护士可以用来帮助患者及其家人应对这种神秘功能障碍的潜在和新兴干预措施。
During and following chemotherapy, some patients experience difficulties with memory, attention, and other aspects of cognitive function. This constellation of deficits commonly is referred to as chemo brain. Although the phenomenon is not understood completely, it is assuming greater significance as cancer survival improves. Return to prediagnosis levels of domestic, employment, and academic activity is expected in most survivors. Advances in basic, imaging, and clinical sciences are beginning to unravel pathophysiologic mechanisms and develop neuroprotective strategies. Pharmacologic options are borrowed from diverse diseases, including attention-deficit/hyperactivity disorder and neurodegenerative diseases. Conventional therapies soon may find new applications; for example, recent preclinical data suggest that erythropoietin may have some neuroprotective abilities, which may positively affect patients experiencing chemo brain. A collaborative model is bringing together international specialists interested in unraveling the mysteries of the phenomenon and developing management strategies to attenuate its effects. This article will review the clinical features of chemo brain as well as a working hypothesis regarding pathophysiology. The potential and emerging interventions that can be used by oncology nurses to assist patients and their families to cope with this enigmatic dysfunction will be discussed.