GLUCOSE METABOLIC-RATE IN NORMALS AND SCHIZOPHRENICS DURING THE CONTINUOUS PERFORMANCE-TEST ASSESSED BY POSITRON EMISSION TOMOGRAPHY
GLUCOSE METABOLIC-RATE IN NORMALS AND SCHIZOPHRENICS DURING THE CONTINUOUS PERFORMANCE-TEST ASSESSED BY POSITRON EMISSION TOMOGRAPHY
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DOI：
10.1192/bjp.156.2.216
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发表时间：
1990-02-01
影响因子：
10.5
通讯作者：
GUICH, S
中科院分区：
文献类型：
--
作者：
BUCHSBAUM, MS;NUECHTERLEIN, KH;GUICH, S
对13例精神分裂症患者和37名右撇子志愿者进行了位置发射断层扫描，测量了氟-18标记的局部脑葡萄糖摄取。患者至少31天没有接受药物治疗，平均30周。在连续表现测试（Continuous Performance Test）中，受试者在一组32分钟的模糊数字序列开始后被给予标记脱氧葡萄糖作为视觉刺激。在正常对照中，任务表现与右额叶和右颞顶叶区域葡萄糖代谢率的增加有关；枕部频率不变。与正常对照相比，精神分裂症患者在额叶皮层和颞顶叶区域的代谢率绝对和相对降低。
Local cerebral uptake of glucose labelled with fluorine-18 was measured by position emission tomography in 13 patients with schizophrenia and 37 right-handed volunteers. Patients received no medication for a minimum of 31 days and a mean of 30 weeks. The subjects were administered the labelled deoxyglucose just after the beginning of a 32-minute sequence of blurred numbers as visual stimuli for the Continuous Performance Test. In normal controls, task performance was associated with increases in glucose metabolic rate in the right frontal and right temporoparietal regions; occipital rates were unchanged. Patients with schizophrenia showed both absolutely and relatively reduced metabolic rates in the frontal cortex and in the temporoparietal regions compared with normal controls.