Olfactory Cortex Generates Synchronized Top-Down Inputs to the Olfactory Bulb during Slow-Wave Sleep
Olfactory Cortex Generates Synchronized Top-Down Inputs to the Olfactory Bulb during Slow-Wave Sleep
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DOI：
10.1523/jneurosci.6578-10.2011
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发表时间：
2011-06-01
影响因子：
5.3
通讯作者：
Mori, Kensaku
中科院分区：
文献类型：
--
作者：
Manabe, Hiroyuki;Kusumoto-Yoshida, Ikue;Mori, Kensaku
在慢波睡眠期间，嗅觉皮层在功能上与外部气味世界隔离。然而，嗅觉皮层的神经元活动模式及其在慢波睡眠期间的功能作用尚不清楚。在这里，我们在自由行为的大鼠中证明，前梨状皮层（嗅觉皮层的主要区域）反复产生尖锐的波，并伴随着大量皮层神经元的同步放电。嗅觉皮层尖波的发生相对独立于海马尖波。电流源密度分析表明，尖锐波的产生涉及嗅觉皮层中锥体细胞的循环关联纤维突触的参与。在慢波睡眠期间，嗅球显示出与嗅皮层锐波同步的锐波，表明嗅皮层锐波驱动同步的自上而下的输入到嗅球。基于这些结果，我们推测嗅觉皮层尖波可能在慢波睡眠期间延髓神经元回路的重组中发挥作用。
The olfactory cortex is functionally isolated from the external odor world during slow-wave sleep. However, the neuronal activity pattern in the olfactory cortex and its functional roles during slow-wave sleep are not well understood. Here, we demonstrate in freely behaving rats that the anterior piriform cortex, a major area of the olfactory cortex, repeatedly generates sharp waves that are accompanied by synchronized discharges of numerous cortical neurons. Olfactory cortex sharp waves occurred relatively independently of hippocampal sharp waves. Current source density analysis showed that sharp wave generation involved the participation of recurrent association fiber synapses to pyramidal cells in the olfactory cortex. During slow-wave sleep, the olfactory bulb showed sharp waves that were in synchrony with olfactory cortex sharp waves, indicating that olfactory cortex sharp waves drove synchronized top-down inputs to the olfactory bulb. Based on these results, we speculate that the olfactory cortex sharp waves may play a role in the reorganization of bulbar neuronal circuits during slow-wave sleep.