Interstitial potentials and their change with depth into cardiac tissue.
Interstitial potentials and their change with depth into cardiac tissue.
复制标题
间质电位及其随心脏组织深度的变化。
DOI：
10.1016/s0006-3495(87)83380-5
复制
发表时间：
1987
影响因子：
3.4
通讯作者：
Barr,RC
中科院分区：
文献类型：
--
作者：
Plonsey,R;Barr,RC
隔离的、活性的、可兴奋的纤维的电源强度可以被视为其跨膜电流，作为极好的近似值。跨膜电流只能由细胞内电位确定。但对于多细胞制剂，特别是心室肌，电源强度可能会因间质电位场的存在而发生显着变化。该报告检查了间质势场的大小与被视为合胞体的心肌的半无限组织结构的深度的函数。假设激励平面波均匀传播，并基于将介质视为连续体（双域模型）来找到间隙势场。总体而言，结果与通常用于表示体积导体的任何限制情况不一致，并且表明只有在最薄的组织（小于 200 微米）中才能忽略间质电位。
The electrical source strength for an isolated, active, excitable fiber can be taken to be its transmembrane current as an excellent approximation. The transmembrane current can be determined from intracellular potentials only. But for multicellular preparations, particularly cardiac ventricular muscle, the electrical source strength may be changed significantly by the presence of the interstitial potential field. This report examines the size of the interstitial potential field as a function of depth into a semi-infinite tissue structure of cardiac muscle regarded as syncytial. A uniform propagating plane wave of excitation is assumed and the interstitial potential field is found based on consideration of the medium as a continuum (bidomain model). As a whole, the results are inconsistent with any of the limiting cases normally used to represent the volume conductor, and suggest that in only the thinnest of tissue (less than 200 micron) can the interstitial potentials be ignored.