The Developmental and Morphological Studies on the Neural and Skeletal Abnormalities in the T/btm Tailless Mice
The Developmental and Morphological Studies on the Neural and Skeletal Abnormalities in the T/btm Tailless Mice
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T/btm无尾小鼠神经和骨骼异常的发育和形态学研究
DOI：
10.1111/j.1440-169x.1994.00409.x
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发表时间：
1994
期刊：
影响因子：
4.6
通讯作者：
T. Tomita
中科院分区：
文献类型：
--
作者：
A. Fujimoto;N. Wakasugi;T. Tomita
用T/+或T/tw 2 ×btm/btm杂交，无尾小鼠的发生率达50%，并对其发育进行了研究。在妊娠9天时，胚胎的外观没有差异。然而，在组织学检查中，一些胚胎显示脊索和神经管在身体后部融合。在妊娠10天时，通过尾根的收缩，可以将预期的无尾个体与正常同窝仔区分开来。此后，它们表现出几种异常，如身体后部生长不良、尾巴变薄以及尾尖或腰骶区出现血疱。11-12天的异常胚胎在中背区域表现出更严重的异常，即，脊索多处分支或变性，神经管扭曲、复制或与间充质融合。所有无尾仔鼠腰骶部中部背部皮肤均出现血疱或红色瘢痕。
The crosses, T/+ or T/tw2×btm/btm, give rise to 50% incidence of the tailless mice, development of which was investigated. No difference was seen in external appearance of the embryos at 9 days of gestation. However, some embryos showed fusion of the notochord and the neural tube at the posterior part of the body on the histological examination. The prospective tailless individuals were distinguishable from the normal littermates by the constriction of the root of the tail at 10 days of gestation. Thereafter, they showed several abnormalities such as the poor growth of the posterior part of the body, thinning of the tail and a blood blister at the tail tip or in the lumbosacral region. The abnormal embryos of 11–12 days showed severer abnormalities in the medio‐dorsal area, i.e., the notochord was branched or degenerated at several places and the neural tube was distorted, duplicated or fused with the mesenchyme. All the tailless newborn young had blood blisters or red scars on the dorsal skin at the middle of the lumbosacral region.
一种新的突变 (t-int) 与影响尾部的小鼠 T/t 复合体的突变相互作用。
影响因子：
3.3
作者：
Artzt,K;Cookingham,J;Bennett,D
通讯作者：
Bennett,D
神经管缺陷小鼠模型：缩减（Tc）突变在 Tc/ 动物中产生隐性脊柱裂，在 Tc/t 动物中产生伴有脑膜脊髓膨出的脊柱裂。
DOI：
10.1002/tera.1420390312
发表时间：
1989
期刊：
Teratology
影响因子：
--
作者：
Park,CH;Pruitt,JH;Bennett,D
通讯作者：
Bennett,D