Pulmonary effects in workers exposed to indium metal: A cross-sectional study
Pulmonary effects in workers exposed to indium metal: A cross-sectional study
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DOI：
10.1539/joh.14-0262-oa
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发表时间：
2015-07-01
影响因子：
3
通讯作者：
Omae, Kazuyuki
中科院分区：
文献类型：
--
作者：
Nakano, Makiko;Tanaka, Akiyo;Omae, Kazuyuki
暴露于铟金属的工人的肺部影响：横断面研究：中野真纪子等庆应义塾大学医学部预防医学与公共卫生系目标：铟于2013年被添加到《特定化学物质危害预防条例》（OPHSCS）规定的物质列表中。然而，由于暴露后对肺部影响的信息不足，金属铟（IM）不受OPHSCS的监管。方法：2011 - 2013年，对11家工厂的141名IM接触工人进行横断面研究。评估主观症状，包括血清生物标志物水平、肺功能测定读数以及总肺容量和弥散肺容量。选择Krebs von den Lungen-6（KL-6）和表面活性蛋白D（SP-D）作为间质性肺炎的生物标志物。铟血清浓度（In-S）和个人空气采样数据被用来估计接触。根据职业和接触类型，将受试者分为5组：冶炼、焊接、牙科技师、粘合和其他。结果：In-S最高值为25.4 μ g/，冶炼组In-S平均值显著高于其他各组。冶炼组中In-S水平升高的患病率为9.1%，而KL-6异常的患病率为15.2%。In-S和KL-6水平之间存在显著的剂量-效应关系。在SP-D值、肺部症状或肺功能检查结果方面，任何组之间均未观察到显著差异。共有31%的受试者在IM水平超过0.3 μ g/m3的环境中工作，这需要佩戴防护口罩。结论：对于暴露于IM的工人，应监测工作环境，应佩戴适当的防护口罩，并应根据OPHSCS进行医疗监测。
Pulmonary effects in workers exposed to indium metal: A cross-sectional study: Makiko NAKANO, et al. Department of Preventive Medicine and Public Health, Keio University School of Medicine Objectives: Indium was added to the list of substances regulated by the Ordinance on Prevention of Hazards due to Specified Chemical Substances (OPHSCS) in 2013. Indium metal (IM), however, is not regulated by the OPHSCS due to insufficient information on pulmonary effects following exposure. Methods: From 2011 to 2013, a cross-sectional study was conducted on 141 IM-exposed workers at 11 factories. Subjective symptoms were assessed, including levels of serum biomarkers, spirometry readings and total and diffuse lung capacity. Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D) were selected as biomarkers of interstitial pneumonia. Indium serum concentration (In-S) and personal air sampling data were used to estimate exposure. Subjects were categorized into 5 groups based on occupation and type of exposure: smelting, soldering, dental technician, bonding and other. Results: The highest level of In-S was 25.4 mu g//, and the mean In-S level was significantly higher in the smelting group than in other groups. In the smelting group, the prevalence of increased In-S levels was 9.1%, while that of abnormal KL-6 was 15.2%. A significant dose-effect relationship was observed between the In-S and KL-6 levels. No marked differences were observed between any of the groups in SP-D values, pulmonary symptoms, or pulmonary function test results. A total of 31% of the subjects worked in an environment with IM levels exceeding 0.3 mu g/m(3), which requires a protective mask to be worn. Conclusions: For workers exposed to IM, work environments should be monitored, appropriate protective masks should be worn, and medical monitoring should be conducted according to the OPHSCS.