The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery.
The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery.
复制标题
DOI：
10.1097/wad.0b013e318191c7dd
复制
发表时间：
2009-04
影响因子：
2.1
通讯作者：
Morris JC
中科院分区：
文献类型：
--
作者：
Weintraub S;Salmon D;Mercaldo N;Ferris S;Graff-Radford NR;Chui H;Cummings J;DeCarli C;Foster NL;Galasko D;Peskind E;Dietrich W;Beekly DL;Kukull WA;Morris JC
国家老龄研究所(NIA)阿尔茨海默病中心(ADC)项目的统一数据集(UDS)神经心理学测试组合包括对注意力、处理速度、执行功能、情景记忆和语言的简要测量。这篇文章描述了电池的开发，以及在使用前24个月收集的3268名临床认知正常的男性和女性的初步UDS评估的初步数据。这些受试者代表了社区居住的样本，即自愿参加认知老化研究的个人。根据包括临床痴呆症评定量表和功能评估问卷在内的临床评估，受试者被认为是“临床认知正常”。结果表明，在相对受过良好教育的样本中，对认知老化和阿尔茨海默病(AD)早期阶段敏感的测试表现良好。研究年龄、教育程度和性别对考试成绩影响的回归模型表明，这些变量需要纳入后续的规范性研究。未来的计划包括：1)确定电池的心理测量学特性；2)建立标准化数据，包括不同少数民族群体的常模；3)对认知正常的受试者、轻度认知障碍的个人、阿尔茨海默病和其他形式的痴呆症患者进行纵向研究。
The neuropsychological test battery from the Uniform Data Set (UDS) of the Alzheimer’s Disease Centers (ADC) program of the National Institute on Aging (NIA) consists of brief measures of attention, processing speed, executive function, episodic memory and language. This paper describes development of the battery and preliminary data from the initial UDS evaluation of 3,268 clinically cognitively normal men and women collected over the first 24 months of utilization. The subjects represent a sample of community-dwelling, individuals who volunteer for studies of cognitive aging. Subjects were considered “clinically cognitively normal” based on clinical assessment, including the Clinical Dementia Rating scale and the Functional Assessment Questionnaire. The results demonstrate performance on tests sensitive to cognitive aging and to the early stages of Alzheimer disease (AD) in a relatively well-educated sample. Regression models investigating the impact of age, education, and gender on test scores indicate that these variables will need to be incorporated in subsequent normative studies. Future plans include: 1) determining the psychometric properties of the battery; 2) establishing normative data, including norms for different ethnic minority groups; and 3) conducting longitudinal studies on cognitively normal subjects, individuals with mild cognitive impairment, and individuals with AD and other forms of dementia.