Meta-Analysis of Aldehyde Dehydrogenase 2 Gene Polymorphism and Alzheimer's Disease in East Asians
Meta-Analysis of Aldehyde Dehydrogenase 2 Gene Polymorphism and Alzheimer's Disease in East Asians
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DOI：
10.1017/s0317167100011938
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发表时间：
2011-05-01
影响因子：
3
通讯作者：
Zhang, Yun
中科院分区：
文献类型：
--
作者：
Hao, Pan-Pan;Chen, Yu-Guo;Zhang, Yun
背景资料：线粒体乙醛脱氢酶2（ALDH 2）基因多态性与阿尔茨海默病（AD）的关联一直存在争议，仅在几个小样本研究中进行了研究。在本研究中，我们进行了一项荟萃分析，以评估东亚人群中ALDH 2变异与AD风险的横断面关联。研究方法：通过MEDLINE、EMBASE、J-STAGE和中国国家知识网络数据库（1994年1月1日至2010年11月1日）检索试验，无任何语言限制。通过标准化方案提取数据。结果：我们发现了四项研究，821例AD患者和1380名健康对照，符合分析。ALDH 2基因型GA/AA变异与AD风险增加无关（比值比（OR）= 1.35; 95%可信区间（CI）= 0.75-2.42; p = 0.32），即使在对载脂蛋白E β 4等位基因状态进行分层后也是如此。然而，在亚组分析中，男性的相关性显著（OR = 1.72; 95% CI = 1.10-2.67; p = 0.02）。结论：这项研究增加了ALDH 2 GA/AA基因型增加东亚男性AD风险的证据，尽管效应大小适中。
Background: The association of genetic polymorphism of mitochondrial aldehyde dehydrogenase 2 (ALDH2) and Alzheimer's disease (AD) has been controversial and has been investigated only in several small-sample studies. In the present study, we performed a meta-analysis to evaluate the cross-sectional association of ALDH2 variants and AD risk in East Asian populations. Methods: Trials were retrieved through MEDLINE, EMBASE, J-STAGE and the China National Knowledge Internet databases (from January 1, 1994 to November 1, 2010) without any restriction on language. Data were abstracted by a standardized protocol. Results: We found four studies of 821 AD patients and 1380 healthy controls that qualified for the analysis. The variant ALDH2 genotype GA/AA was not associated with increased AD risk (odds ratio (OR) = 1.35; 95% confidence interval (CI) = 0.75-2.42; p = 0.32), even after stratification for the status of apolipoprotein E epsilon 4 allele. However, in the subgroup analyses, the association was significant for men (OR = 1.72; 95% CI = 1.10-2.67; p = 0.02). Conclusions: This study adds to the evidence that ALDH2 GA/AA genotype increases the risk of AD among East Asian men, although the effect size is moderate.