THE INTERRELATIONSHIP OF SOME FACTORS INFLUENCING RENAL BLOOD FLOW AUTOREGULATION.
THE INTERRELATIONSHIP OF SOME FACTORS INFLUENCING RENAL BLOOD FLOW AUTOREGULATION.
复制标题
影响肾血流自动调节的一些因素的相互关系。
DOI：
10.1111/j.1748-1716.1964.tb02952.x
复制
发表时间：
1964
期刊：
影响因子：
--
通讯作者：
J. Langston
中科院分区：
文献类型：
--
作者：
B. Folkow;J. Langston
B.福尔科夫和兰斯顿：影响肾血流量自动调节的某些因素的相互关系。《生理学学报》，1964年。61. 165-176.-对猫进行了一项研究，涉及产生肾血流自动调节的“主动”和“被动”局部机制的相互关系，这些机制被肾血管收缩纤维的中枢影响所抵消。实验表明，“主动”机制完全占主导地位，在中等或较高的血压水平，但也是“被动”的一个显着贡献，在较低的压力或每当“主动”机制失败。然而，这些自动调节机制可能或多或少完全被血管收缩纤维活性所压倒，这使得肾血管回路表现为被动弹性管系统。这些研究结果的一些影响进行了简要的讨论。负责“自动调节”的区域血流的机制引起了相当大的兴趣，在某种程度上，最近的国际研讨会（1963年）致力于这个问题。特别是肾血流量的明显的自动调节一直是一个有很大争议的问题，争论主要集中在生理情况下，是一个“主动”的局部血管调节还是一个纯粹的“被动”机制负责自动调节。关于第一种可能性，Bayliss（1902）的假设，暗示血压提供的扩张可能作为血管平滑肌的适当刺激，已经进行了大量讨论。这样一个概念，这似乎是在很好的协议，到目前为止，众所周知的特点，其他类型的肌活性平滑肌，其基本要素已被实验验证，至少在一些血管床。
FOLKOW, B. and J. LANGSTON: Th interrelationship of some factors injuencing renal blood jow autoregulation. Acta physiol. scand. 1964. 61. 165-176.-A study has been performed on cats concerning the interrelationship of ‘active’and ‘passive’local mechanisms for producing renal blood flow autoregulation, as counteracted by the centrally directed influence of the renal vasoconstrictor fibres. The experiments indicate that the ‘active’mechanism dominates completely at moderate or higher blood pressure levels, but also that the ‘passive’one contributes significantly at lower pressures or whenever the ‘active’mechanism fails. However, these autoregulatory mechanisms can be more or less completely overwhelmed by a vasoconstrictor fibre activity, which makes the renal vascular circuit behave as a passive-elastic tube system. Some implications of these findings are briefly discussed.The mechanisms responsible for ‘autoregulation’of regional blood flow have aroused considerable interest, to the extent that a recent international symposium (1963) was devoted to this problem. Especially the pronounced autoregulation of renal blood flow has been a matter of much controversy, and the debate has mainly been concentrated to the question whether under physiological circumstances an ‘active’local vascular adjustment or a purely ‘passive’mechanism is responsible for the autoregulation. Concerning the first mentioned possibility, the hypothesis of Bayliss (1902), implying that the distension offered by the blood pressure might serve as an adequate stimulus for the vascular smooth muscles, has been much discussed. Such a concept, which seems to be in good agreement with by now well known characteristics of other types of myogenically active smooth muscles, has in its essential elements been experimentally validated, at least in some vascular beds.