Linking estrogen to Alzheimer's disease: An informatics approach
Linking estrogen to Alzheimer's disease: An informatics approach
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DOI：
10.1212/wnl.47.3.809
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发表时间：
1996-09-01
期刊：
影响因子：
9.9
通讯作者：
Swanson, DR
中科院分区：
文献类型：
--
作者：
Smalheiser, NR;Swanson, DR
流行病学研究表明，雌激素可以预防AD。我们使用Arrowsmith，一种新的计算机辅助方法，通过搜索已知的雌激素作用目标和与AD相关的单独研究的物质或过程，来确定雌激素和AD之间的可能联系，这些联系在生物医学文献中并不明确。有几个联系似乎特别有希望(例如，雌激素的抗氧化活性)，值得神经科学家关注。
Epidemiologic studies suggest that estrogen protects against AD. We employ ARROWSMITH, a novel computer-assisted approach, to identify possible links between estrogen and AD that are not explicit in the biomedical literature, by searching for substances or processes that are known targets of estrogen action and that have also been separately studied in relation to AD. Several links appear particularly promising (e.g., estrogen's antioxidant activity) and merit attention by neuroscientists.