Association of posttherapy positron emission tomography with tumor response and survival in cervical carcinoma
Association of posttherapy positron emission tomography with tumor response and survival in cervical carcinoma
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DOI：
10.1001/jama.298.19.2289
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发表时间：
2007-11-21
影响因子：
120.7
通讯作者：
Grigsby, Perry W.
中科院分区：
文献类型：
--
作者：
Schwarz, Julie K.;Siegel, Barry A.;Grigsby, Perry W.
背景 回顾性研究表明，在宫颈癌患者的治疗后评估中使用正电子发射断层扫描 (PET) 和 F-18 氟脱氧葡萄糖 (FDG) 可预测生存结果。目的 验证治疗后 3 个月 FDG-PET 的代谢反应与长期生存结果之间的关联。设计、设置和患者 一项前瞻性队列研究旨在验证我们之前的发现，即治疗后 3 个月的结果FDG-PET 可预测长期临床结果。 2003年1月至2006年9月，共有92名女性接受了外照射、近距离放射治疗和同步化疗。治疗完成后2～4个月（平均3个月）进行全身FDG-PET。主要观察指标主要观察终点为代谢反应、无进展生存期和病因特异性生存期。结果 65例患者治疗后FDG-PET显示完全代谢反应(70%)，15 例 (16%) 出现部分代谢反应，12 例 (13%) 出现疾病进展。他们的 3 年无进展生存率分别为 78%、33% 和 0%（P
Context Retrospective studies have demonstrated that the use of positron emission tomography ( PET) with F-18 fluorodeoxyglucose (FDG) in the posttherapy evaluation of patients with cervical carcinoma is predictive of survival outcome.Objective To validate the association between the metabolic response on the 3-month posttherapy FDG-PET and long-term survival outcome.Design, Setting, and Patients A prospective cohort study designed to validate our previous finding that the results of a 3-month posttherapy FDG-PET are predictive of long-term clinical outcome. A total of 92 women were treated with external irradiation, brachytherapy, and concurrent chemotherapy from January 2003 through September 2006. Posttherapy whole-body FDG-PET was performed 2 to 4 months ( mean, 3 months) after completion of therapy.Main Outcome Measures The primary outcome end points were metabolic response, progression-free survival, and cause-specific survival.Results Posttherapy FDG-PET showed a complete metabolic response in 65 patients (70%), a partial metabolic response in 15 (16%),and progressive disease in 12 (13%). Their 3-year progression-free survival rates were 78%, 33%, and 0%, respectively ( P