Age thresholds for changes in semen parameters in men
Age thresholds for changes in semen parameters in men
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DOI：
10.1016/j.fertnstert.2013.05.046
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发表时间：
2013-10-01
影响因子：
6.7
通讯作者：
Marrs, Richard P.
中科院分区：
文献类型：
--
作者：
Stone, Bronte A.;Alex, Allyse;Marrs, Richard P.
目的：确定精液质量要素是否存在年龄阈值。设计：对4,822份精液分析和259份荧光原位杂交（FISH）分析结果进行回顾性分析（协方差和点变化分析）。设置：不孕不育诊所内的参考实验室。患者：男性5081例，年龄16.5 ~ 72.3岁。干预:没有。主要观察指标：射精量、精子浓度、精子活力、精子运动参数、严格形态学和FISH分析结果。结果：射精测量参数在34岁前没有变化。此后不久，精子总数（和总活动量）下降。精子浓度和正常形态精子比例在40年后下降。43年后，精子活力和运动精子的进展参数下降，45年后，射精量下降。射精中携带Y: x染色体的精子比例在55年后才下降。结论：我们的研究结果表明，与34岁以上的男性性交后怀孕的可能性下降，与女性的年龄无关，并随着年龄的增长而增加。年龄相关的机制与这种少弱异生精子的进展进行了讨论。肥料(R) 2013；100: 952 - 8。(C) 2013年由美国生殖医学学会出版。)
Objective: To determine whether age thresholds for elements of semen quality exist.Design: Retrospective analysis (covariance and point-change analysis) of results of 4,822 semen analyses and 259 fluorescence in situ hybridization (FISH) analyses.Setting: Reference laboratory within an infertility clinic.Patient(s): A total of 5,081 men aged 16.5-72.3 years.Intervention(s): None.Main Outcome Measure(s): Ejaculate volume, sperm concentration, sperm motility, sperm motion parameters, strict morphology, and results of FISH analysis.Result(s): Measured parameters of ejaculates did not change before 34 years of age. Immediately thereafter, total sperm numbers (and total motile) declined. Sperm concentration and the proportion of sperm of normal morphology declined after 40 years. Sperm motility and progressive parameters of motile sperm fell after 43 years and ejaculate volume after 45 years. The ratio of Y: X-bearing sperm in ejaculates decreased only after 55 years.Conclusion(s): Our findings project a declining likelihood of pregnancy following intercourse with men >34 years old, independent from the woman's age and increasing with advancing age. Age-related mechanisms associated with this oligoasthenoteratozoospermic progression are discussed. (Fertil Steril (R) 2013; 100: 952-8. (C) 2013 by American Society for Reproductive Medicine.)