Distribution of emphysema in heavy smokers: Impact on pulmonary function
Distribution of emphysema in heavy smokers: Impact on pulmonary function
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DOI：
10.1016/j.rmed.2009.08.004
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发表时间：
2010-01-01
影响因子：
4.3
通讯作者：
Lammers, Jan Willem J.
中科院分区：
文献类型：
--
作者：
Gietema, Hester A.;Zanen, Pieter;Lammers, Jan Willem J.
目的：调查计算机断层扫描 (CT) 肺气肿的分布对参加肺癌筛查试验的当前和以前的重度吸烟者的气流受限和气体交换损伤严重程度的影响。材料和方法：作为荷兰-比利时肺癌筛查试验 (NELSON) 的一部分，总共 875 名当前和以前的重度吸烟者在我们中心接受了基线双剂量 CT (30 mAs) 以及肺活量测定和扩散能力测试。 872 名受试者的肺气肿被量化为具有明显高 X 射线衰减系数的体素数量。体素衰减
Purpose: To investigate impact of distribution of computed tomography (CT) emphysema on severity of airflow limitation and gas exchange impairment in current and former heavy smokers participating in a tung cancer screening trial.Materials and Methods: In total 875 current and former heavy smokers underwent baseline tow-dose CT (30 mAs) in our center and spirometry and diffusion capacity testing on the same day as part of the Dutch-Belgian Lung Cancer Screening Trial (NELSON). Emphysema was quantified for 872 subjects as the number of voxels with an apparent towered X-ray attenuation coefficient. Voxels attenuated