Abnormalities in brain white matter in adolescents with 22q11.2 deletion syndrome and psychotic symptoms.
Abnormalities in brain white matter in adolescents with 22q11.2 deletion syndrome and psychotic symptoms.
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DOI：
10.1007/s11682-016-9602-x
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发表时间：
2017-10
影响因子：
3.2
通讯作者：
Kates WR
中科院分区：
文献类型：
--
作者：
Kikinis Z;Cho KIK;Coman IL;Radoeva PD;Bouix S;Tang Y;Eckbo R;Makris N;Kwon JS;Kubicki M;Antshel KM;Fremont W;Shenton ME;Kates WR
22q11.2缺失综合征（22q11DS）被认为是一个有前途的队列，以探索精神分裂症风险的生物标志物，基于30%的概率在成年期发展为精神分裂症。在这项研究中，我们调查了22 q11 DS青少年白色物质的微结构异常及其对精神分裂症前驱症状的特异性。弥散磁共振成像（dMRI）数据采集自50例22q11DS受试者（9例有前驱精神病症状，41例无前驱精神病症状）和47例匹配的健康对照（平均年龄18 ± 2岁）。使用基于道的空间统计（TBSS）方法计算并比较各组之间的DMRI指标，包括各向异性分数（FA）、平均扩散率（MD）、轴向扩散率（AD）和径向扩散率（RD）。此外，进行了dMRI测量和阳性症状评分之间的相关性。在整个22 q11 DS组中，在胼胝体（CC）、左右上级纵束（SLF）和左右放射冠中发现MD、AD和RD（但不FA）减少。此外，与非前驱亚组相比，22q11DS亚组的前驱症状AD和MD降低，但RD无变化，CC、右侧SLF、右侧放射冠和右侧内囊。最后，AD值在这些路段与精神病分量表的分数。具有前驱精神病症状的青少年受试者存在脑白色物质的显微结构异常。
22q11.2 Deletion Syndrome (22q11DS) is considered to be a promising cohort to explore biomarkers of schizophrenia risk based on a 30% probability of developing schizophrenia in adulthood. In this study, we investigated abnormalities in the microstructure of white matter in adolescents with 22q11DS and their specificity to prodromal symptoms of schizophrenia. Diffusion Magnetic Resonance Imaging (dMRI) data were acquired from 50 subjects with 22q11DS (9 with and 41 without prodromal psychotic symptoms), and 47 matched healthy controls (mean age 18 +/-2 years). DMRI measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated and compared between groups using the Tract Based Spatial Statistics (TBSS) method. Additionally, correlations between dMRI measures and scores on positive symptoms were performed. Reductions in MD, AD and RD (but not FA) were found in the corpus callosum (CC), left and right superior longitudinal fasciculus (SLF), and left and right corona radiata in the entire 22q11DS group. In addition, the 22q11DS subgroup with prodromal symptoms showed reductions in AD and MD, but no changes in RD when compared to the non-prodromal subgroup, in CC, right SLF, right corona radiata and right internal capsule. Finally, AD values in these tracts correlated with the scores on the psychosis subscale. Microstructural abnormalities in brain white matter are present in adolescent subjects with prodromal psychotic symptoms.