Animal tests of anxiety.
Animal tests of anxiety.
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DOI：
10.1002/0471142301.ns0803s26
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发表时间：
2004-05-01
影响因子：
--
通讯作者：
Lippa, Morgen T
中科院分区：
文献类型：
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作者：
File, Sandra E;Lippa, Arnold S;Lippa, Morgen T
焦虑的动物试验用于筛选抗焦虑或致焦虑活性的新型化合物，研究焦虑的神经生物学，并评估其他事件的影响，如暴露于捕食者气味或早期饲养经验。本单元介绍了最常用的焦虑动物试验方案。Geller-Seifter冲突测试，社会互动测试，明/暗探索，高架十字迷宫，防御性埋葬和口渴的大鼠冲突。该协议是在药物筛选测试方面进行描述的，但可以很容易地修改为其他目的。
Animal tests of anxiety are used to screen novel compounds for anxiolytic or anxiogenic activity, to investigate the neurobiology of anxiety, and to assess the impact of other occurrences such as exposure to predator odors or early rearing experiences. This unit presents protocols for the most commonly used animal tests of anxiety. The Geller-Seifter conflict test, the social interaction test, light/dark exploration, the elevated plus-maze, defensive burying, and the thirsty rat conflict. The protocols are described in terms of drug screening tests, but can be modified easily for other purposes.