A Comparative Study of Physical Performance Measures in Parkinson's Disease
A Comparative Study of Physical Performance Measures in Parkinson's Disease
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DOI：
10.1002/mds.22266
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发表时间：
2008-10-15
影响因子：
8.6
通讯作者：
Shulman, Lisa M.
中科院分区：
文献类型：
--
作者：
Tanji, Haruko;Gruber-Baldini, Ann L.;Shulman, Lisa M.
这项研究的目的是比较体能指标在帕金森氏病(PD)中区分残疾程度和疾病严重程度的能力。帕金森病患者的残疾通常通过患者自我报告来评估，这可能会受到患者洞察力的限制。方法：采用体能测试(PPT)、改良体能测试(MPPT)对79例帕金森病患者进行测试。短物理性能电池(SPPB)。日常生活活动能力测验(PADL)。伯格平衡量表(BBS)。计时起跑(TUG)和功能伸展(FR)。将这些衡量标准与老年美国人资源和服务残疾子量表(OARS)中患者报告的残疾情况以及统一帕金森氏病评定量表(UPDRS)中的疾病严重程度进行比较。绩效指标对疾病严重程度比残疾程度更敏感。四项指标在残疾的四分位数中受到歧视(PPT、MPPT、BBS、TUG：P<；0.05)，而所有七项指标在UPDR总量的四分位数中都受到歧视(PPT、MPPT、BBS、TUG、FR：P<；0.01；SPPB、PADL：P<；0.05)。然而，没有一种衡量标准一致地区分早期和晚期疾病严重程度不同的亚组。所测量的七项体能表现在评估残疾和疾病严重程度方面显示出不同的优势和劣势。本研究结果将有助于选择帕金森病临床护理和临床试验的绩效指标。(C)2008年运动无序协会。
The objective of this study is to compare physical performance measures for their ability to discriminate between levels of disability and disease severity in Parkinson's disease (PD). Disability in PD is commonly assessed by patient self-report, which may be limited by patient insight. Methods: Seventy-nine patients with PD were tested with seven performance measures: Physical Performance Test (PPT) modified Physical Performance Test (mPPT). Short Physical Performance Battery (SPPB). Performance Test of Activities of Daily Living (PADL). Berg Balance Scale (BBS). Timed Up and Go (TUG), and Functional Reach (FR). These measures were compared with patient-reported disability on the Older Americans Resource and Services Disability subscale (OARS) and disease severity on the Unified Parkinson's Disease Rating Scale (UPDRS). The performance measures were more sensitive to levels of disease severity than disability. Four measures discriminated across quartiles of disability (PPT, mPPT, BBS, TUG: P < 0.05), whereas all seven measures discriminated across quartiles of the Total UPDRS (PPT, mPPT, BBS, TUG, FR: P < 0.01; SPPB, PADL: P < 0.05). However, no measure consistently discriminated between subgroups with a range of early and advanced disease severity. The seven physicla performance measured showed different profiles of strengths and weaknesses in assessing disability and disease severity. The results of this study will facilitate choosing performance measures for clinical care and clinical trials in PD. (C) 2008 Movement Disorder Society.