High-Intensity Focused Ultrasound: Heating and Destruction of Biological Tissue
High-Intensity Focused Ultrasound: Heating and Destruction of Biological Tissue
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DOI：
10.1134/s1063784220090030
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发表时间：
2020-09-01
影响因子：
0.7
通讯作者：
Lukin, A. Ya.
中科院分区：
文献类型：
--
作者：
Andreeva, T. A.;Berkovich, A. E.;Lukin, A. Ya.
给出了在由多元阵列(肿瘤治疗方案)产生的一系列聚焦超声脉冲作用下生物组织加热和破坏的数值研究结果。考虑的照射方案在组织内焦点的位置(阿基米德螺旋和正方形螺旋)、序列中的脉冲数量以及脉冲之间的时间延迟方面不同。在所考虑的中等辐射强度范围内，脉冲序列和灌流过程的参数对组织中热损伤区域的大小有显著影响。结果表明，组织中的热传播过程随时间转变为准球形模式，且与照射方案类型的依赖性较弱。根据其可能用于优化利用聚焦超声的医疗程序的方案，讨论了该过程的这一特征。
The results of a numerical study of heating and destruction of a biological tissue under the action of a series of focused ultrasound pulses generated by a multielement array (tumor treatment programs) are presented. Irradiation programs are considered that differ in the locations of focal points within a tissue (the Archimedean and "square" spirals), the number of pulses in the series, and the time delay between pulses. A significant influence of the parameters of the pulse series and perfusion process on the size of the thermal lesion area in a tissue was established in a considered range of moderate intensities of radiation. It was shown that the heat propagation process in the tissue turns with time to a quasi-spherical pattern and is weakly dependent on the irradiation program type. This characteristic of the process is discussed in terms of its possible use to optimize protocols of medical procedures utilizing focused ultrasound.