Effect of parathyroid hormone on experimental tooth movement in rats
Effect of parathyroid hormone on experimental tooth movement in rats
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DOI：
10.1016/j.ajodo.2013.05.010
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发表时间：
2013-10-01
影响因子：
3
通讯作者：
Zou, Shujuan
中科院分区：
文献类型：
--
作者：
Li, Fan;Li, Guifeng;Zou, Shujuan
简介：本研究的目的是探讨甲状旁腺激素注射对大鼠实验性牙齿移动的影响。方法：60只雄性Wistar大鼠随机分为2组。他们的上颌右第一磨牙通过镍钛闭合螺旋弹簧向近中移动。实验组每天皮下注射甲状旁腺激素，剂量为每100克体重4微克，持续12天，对照组接受赋形剂注射。通过口腔内测量、苏木精和曙红、抗酒石酸酸性磷酸酶和免疫组织化学染色来评估结果。结果：与对照组相比，甲状旁腺激素组的牙齿移动和破骨细胞数量明显增加。甲状旁腺激素组核因子κB配体受体激活剂和胰岛素样生长因子-I的表达显着增加。结论：数据表明，短期甲状旁腺激素注射可能是通过增加牙槽骨转换率来加速正畸牙齿移动的潜在方法。
Introduction: The aim of this study was to investigate the effect of parathyroid hormone injection on experimental tooth movement in rats. Methods: Sixty male Wistar rats were randomly divided into 2 groups. Their maxillary right first molars were moved mesially with nickel-titanium closed-coil springs. The experimental group received daily subcutaneous injections of parathyroid hormone at a dose of 4 mu g per 100 g of body weight for 12 days, and the control group received vehicle injections. The results were evaluated by intraoral measurements and by hematoxylin and eosin, tartrate-resistant acid phosphatase, and immunohistochemistry staining. Results: The tooth movement and osteoclast numbers were significantly increased in the parathyroid hormone group compared with the control group. The expressions of receptor activator of nuclear factor kappa B ligand and insulin-like growth factor-I were significantly stimulated in the parathyroid hormone group. Conclusions: The data suggest that short-term parathyroid hormone injection might be a potential method for accelerating orthodontic tooth movement by increasing the alveolar bone turnover rate.