Mucin can enhance growth, biofilm formation, and survival of Streptococcus mutans.
Mucin can enhance growth, biofilm formation, and survival of Streptococcus mutans.
复制标题
粘蛋白可以促进变形链球菌的生长、生物膜形成和存活。
DOI：
10.1111/1574-6968.12336
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发表时间：
2014
影响因子：
2.1
通讯作者：
Piggot,PatrickJ
中科院分区：
文献类型：
--
作者：
Mothey,Deepa;Buttaro,BettinaA;Piggot,PatrickJ
变形链球菌是牙菌斑中的一员，是龋齿的主要病原体。它可以在长时间的饥饿中存活，这可能发生在口腔内的不同壁龛中。我们已经发现，粘蛋白弥补了氨基酸的缺乏，以促进指数生长和生物膜形成的S。分别补充有葡萄糖和蔗糖的mutansin基本培养基。在没有净生长的条件下，如果编码丙酮酸脱氢酶复合物的操纵子是完整的，粘蛋白延长了存活时间。在氨基酸充足的条件下，如果半乳糖利用的塔格糖途径是完整的，粘蛋白延长了存活时间，这表明S。突变体可以从粘蛋白中吸收足够的半乳糖来提高存活率，尽管不能作为主要的碳源和能源。结果提示粘蛋白在促进S.变异人
Streptococcus mutansis a member of the dental plaque and is the primary causative agent of dental caries. It can survive extended periods of starvation, which may occur in different niches within the oral cavity. We have found that mucin compensated for the absence of amino acids to promote exponential growth and biofilm formation ofS. mutansin minimal medium supplemented with glucose and sucrose, respectively. Mucin extended survival in conditions where there was no net growth provided the operon encoding the pyruvate dehydrogenase complex was intact. Mucin extended survival in conditions of amino acid sufficiency provided the tagatose pathway for galactose utilization was intact, suggesting thatS. mutanscan scavenge sufficient galactose from mucin to enhance survival, although not to serve as a primary carbon and energy source. The results suggest that mucin has a metabolic role in promoting survival ofS. mutans.