Juvenile xanthogranuloma of the oral cavity in children: A clinicopathologic study
Juvenile xanthogranuloma of the oral cavity in children: A clinicopathologic study
复制标题
DOI：
10.1067/moe.2002.122340
复制
发表时间：
2002-09-01
期刊：
影响因子：
--
通讯作者：
Hicks, J
中科院分区：
文献类型：
--
作者：
Flaitz, C;Allen, C;Hicks, J
目的.本临床病理学研究描述了组织病理学，免疫细胞化学，。目的：探讨儿童口腔幼年黄色肉芽肿的病理学特征及电镜特征。研究人群包括5名儿童（5个月至10岁），活检证实JXG获得咨询。病变部位为牙龈、颊粘膜和舌，临床医生将其描述为（1）刺激性纤维瘤;（2）肉芽组织;（3）有蒂颗粒结节;（4）乳头状瘤样病变;（5）棕红色脐状丘疹。组织可用于组织病理学（n = 5）、免疫细胞化学（n = 5）和超微结构（n = 3）研究。3例早期JXG病变组织细胞丰富，但缺乏土伦巨细胞。另2例为典型的JXG病变，伴有空泡化组织细胞和土伦巨细胞。免疫细胞化学结果为（1）CD 68（01，PGM 1），中度至弥漫性;（2）肌成束蛋白，中度至弥漫性;（3）因子XIIIa，局灶性至弥漫性;（4）α-1-抗胰蛋白酶，中度至弥漫性;（5）S-100蛋白，局灶性至弥漫性;（6）CD 1a，所有病例均为阴性。超微结构显示组织细胞和树突状细胞缺乏Birbeck颗粒。口腔的JXG在临床和组织病理学表现上各不相同，因此必须排除郎格罕氏细胞病（LCD）。在某些儿童中，JXG和朗格汉斯细胞病可能同时发生，在彼此之前或之后。
Purpose. This clinicopathologic study describes the histopathologic, immunocytochemical,. and electron microscopic features of oral juvenile xanthogranuloma (JXG) in children.Design. The study population consisted of 5 children (5 months to 10 years of age) with biopsy-proven JXGs obtained for consultation.Results. Lesion sites were gingiva, buccal mucosa, and tongue and were decribed by the clinicians as (1) irritation fibroma; (2) granulation tissue; (3) pedunculated granular nodule; (4) papilioma-like lesion; and (5) brown-red umbilicated papule. Tissue was available for histopathologic (n = 5), immunocytochemical (n = 5), and ultrastructural (n = 3) studies. Three cases showed early JXG lesions possessing abundant histiocytes, but lacking Toulon giant cells. The other 2 cases had classic JXG lesions with vacuolated histiocytes and Toulon giant cells. Immunocytochemical findings were (1) CD68 (01, PGM1), moderate to diffuse; (2) fascin, moderate to diffuse; (3) factor XIIIa, focal to diffuse; (4) alpha-1-antitrypsin, moderate to diffuse; (5) S-100 protein, focal to diffuse; and (6) CD1a, negative in all cases. Ultrastructural examination displayed histiocytic and dendritic cells lacking pentalaminar structures (Birbeck granules).Conclusion. JXGs of the oral cavity vary in their clinical and histopathologic appearances and necessitate that Langerhans' cell disease (LCD) be excluded. JXG and Langerhans' cell disease may occur concurrently, before or after each other, in some children.