Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing.
Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing.
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DOI：
10.1016/j.devcel.2010.07.018
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发表时间：
2010-08-17
影响因子：
11.8
通讯作者：
Sheetz MP
中科院分区：
文献类型：
--
作者：
Moore SW;Roca-Cusachs P;Sheetz MP
基质和组织刚性指导许多细胞过程，包括干细胞的分化和细胞在健康和疾病中的迁移。细胞使用受固有物理参数限制的机制来主动和瞬时地测试刚性，这些物理参数包括细胞外附着的强度、对这些附着的拉力以及机械转导系统的敏感性。在这里，我们着重于通过细胞外基质受体和连接蛋白的整合素家族介导的刚性感知，并讨论支持这些蛋白作为机械传感器的证据。
Matrix and tissue rigidity guides many cellular processes, including the differentiation of stem cells and the migration of cells in health and disease. Cells actively and transiently test rigidity using mechanisms limited by inherent physical parameters that include the strength of extracellular attachments, the pulling capacity on these attachments, and the sensitivity of the mechanotransduction system. Here we focus on rigidity sensing mediated through the integrin family of extracellular matrix receptors and linked proteins, and discuss the evidence supporting these proteins as mechanosensors.