The many roads to psychosis: recent advances in understanding risk and mechanisms.
The many roads to psychosis: recent advances in understanding risk and mechanisms.
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DOI：
10.12688/f1000research.16574.1
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Forsyth, Jennifer K
中科院分区：
文献类型：
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作者：
Bearden, Carrie E;Forsyth, Jennifer K
精神分裂症是一种慢性和严重的精神疾病，经常导致终身残疾。在过去的五年里，我们在理解这种疾病的复杂遗传结构方面取得了重大进展。理解精神分裂症的核心生物学过程和开发更好的干预措施的两个主要障碍是（1）缺乏病因学定义的生物标志物和（2）该疾病的临床和遗传异质性。在这里，我们回顾了最近的进展，导致我们的理解的变化，涉及精神分裂症的发展的危险因素和机制。特别是，机械和临床导向的方法现在已经集中在早期神经发育和突触可塑性的中断作为理解轨迹和干预改变它们的关键。将这些新发现转化为实质性改变患者生活的治疗方法是该领域的下一个主要挑战。
Schizophrenia is a chronic and severe mental illness which frequently leads to substantial lifelong disability. The past five years have seen major progress in our understanding of the complex genetic architecture of this disorder. Two major barriers to understanding the core biological processes that underlie schizophrenia and developing better interventions are (1) the absence of etiologically defined biomarkers and (2) the clinical and genetic heterogeneity of the disorder. Here, we review recent advances that have led to changes in our understanding of risk factors and mechanisms involved in the development of schizophrenia. In particular, mechanistic and clinically oriented approaches have now converged on a focus on disruptions in early neurodevelopment and synaptic plasticity as being critical for both understanding trajectories and intervening to change them. Translating these new findings into treatments that substantively change the lives of patients is the next major challenge for the field.