Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts
Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts
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DOI：
10.1038/ni1236
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发表时间：
2005-09-01
影响因子：
30.5
通讯作者：
Lanier, LL
中科院分区：
文献类型：
--
作者：
Ogasawara, K;Benjamin, J;Lanier, LL
F-1受体中的抗辐射自然杀伤（NK）细胞可以排斥亲本骨髓，并且宿主NK细胞也可以阻止同种异体骨髓的植入。我们在这里表明，在某些小鼠品系中重新填充骨髓细胞表达视黄酸早期诱导1蛋白，这是活化NKG 2D NK细胞受体的配体。在（C57 BL/ 6 x BALB/ c）F1受体中，使用NKG 2D中和抗体治疗可预防亲代BALB/ c骨髓排斥，并允许同种异体BALB植入。C57 BL/ 6受体的B骨髓。此外，来自维甲酸早期诱导型1 β转基因C57 BL/ 6小鼠的骨髓被同基因小鼠排斥，但在用NKG 2D抗体处理后被接受。如果其他干细胞或组织在移植后上调NKG 2D配体的表达，则NKG 2D可能导致免疫活性宿主的移植物排斥反应。
Irradiation- resistant natural killer ( NK) cells in an F-1 recipient can reject parental bone marrow, and host NK cells can also prevent engraftment of allogeneic bone marrow. We show here that repopulating bone marrow cells in certain mouse strains expressed retinoic acid early inducible 1 proteins, which are ligands for the activating NKG2D NK cell receptor. Treatment with a neutralizing antibody to NKG2D prevented rejection of parental BALB/ c bone marrow in ( C57BL/ 6 x BALB/ c) F1 recipients and allowed engraftment of allogeneic BALB. B bone marrow in C57BL/ 6 recipients. Additionally, bone marrow from C57BL/ 6 mice transgenic for retinoic acid early inducible 1 epsilon was rejected by syngeneic mice but was accepted after treatment with antibody to NKG2D. If other stem cells or tissues upregulate expression of NKG2D ligands after transplantation, NKG2D may contribute to graft rejection in immunocompetent hosts.