Effect of Acute Antidepressant Administration on Negative Affective Bias in Depressed Patients
Effect of Acute Antidepressant Administration on Negative Affective Bias in Depressed Patients
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DOI：
10.1176/appi.ajp.2009.09020149
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发表时间：
2009-10-01
影响因子：
17.7
通讯作者：
Cowen, Philip J.
中科院分区：
文献类型：
--
作者：
Harmer, Catherine J.;O'Sullivan, Ursula;Cowen, Philip J.
目的：抗抑郁药的急性给药增加了健康志愿者的积极情感处理，这种作用可能与这些药物的治疗作用有关。作者调查了这种效果是否是明显的抑郁症患者早期治疗，在情绪和symptoms.Method的变化之前：在一个双盲，安慰剂对照，组间随机设计，作者研究了一个单一的4毫克剂量的去甲肾上腺素再摄取抑制剂reboxaline对情绪处理的影响。通过初级保健诊所和社区招募了33名抑郁症患者，并与31名健康对照受试者进行了匹配。给药后三小时，参与者接受了一系列情绪处理任务，包括面部表情识别，情绪分类和记忆。情绪，焦虑和副作用的评级也获得了治疗前和后treatment.Results：抑郁症患者谁收到安慰剂表现出减少识别积极的面部表情，速度下降，积极的自我相关的人格形容词，并减少记忆这种积极的信息相比，健康志愿者接受安慰剂。然而，这种效果被逆转的患者谁收到了单剂量的reboxeratin，尽管没有变化的主观评级的情绪或anxiety.Conclusions：抗抑郁药管理调制情绪处理抑郁症患者在治疗的早期，发生变化之前的情绪和症状。这种效应可能会改善情绪和焦虑症的特征信息处理的负面偏见。它还表明了一种与抑郁症的认知理论相一致的作用机制。
Objective: Acute administration of an antidepressant increases positive affective processing in healthy volunteers, an effect that may be relevant to the therapeutic actions of these medications. The authors investigated whether this effect is apparent in depressed patients early in treatment, prior to changes in mood and symptoms.Method: In a double-blind, placebo-controlled, between-groups randomized design, the authors examined the effect of a single 4-mg dose of the norepinephrine reuptake inhibitor reboxetine on emotional processing. Thirty-three depressed patients were recruited through primary care clinics and the community and matched to 31 healthy comparison subjects. Three hours after dosing, participants were given a battery of emotional processing tasks comprising facial expression recognition, emotional categorization, and memory. Ratings of mood, anxiety, and side effects were also obtained before and after treatment.Results: Depressed patients who received placebo showed reduced recognition of positive facial expressions, decreased speed in responding to positive self-relevant personality adjectives, and reduced memory for this positive information compared to healthy volunteers receiving placebo. However, this effect was reversed in patients who received a single dose of reboxetine, despite the absence of changes in subjective ratings of mood or anxiety.Conclusions: Antidepressant drug administration modulates emotional processing in depressed patients very early in treatment, before changes occur in mood and symptoms. This effect may ameliorate the negative biases in information processing that characterize mood and anxiety disorders. It also suggests a mechanism of action compatible with cognitive theories of depression.