ACUTE EFFECTS OF NITRIC-OXIDE ON LEFT-VENTRICULAR RELAXATION AND DIASTOLIC DISTENSIBILITY IN HUMANS - ASSESSMENT BY BICORONARY SODIUM-NITROPRUSSIDE INFUSION
ACUTE EFFECTS OF NITRIC-OXIDE ON LEFT-VENTRICULAR RELAXATION AND DIASTOLIC DISTENSIBILITY IN HUMANS - ASSESSMENT BY BICORONARY SODIUM-NITROPRUSSIDE INFUSION
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DOI：
10.1161/01.cir.89.5.2070
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发表时间：
1994-05-01
期刊：
影响因子：
37.8
通讯作者：
SHAH, AM
中科院分区：
文献类型：
--
作者：
PAULUS, WJ;VANTRIMPONT, PJ;SHAH, AM
背景在分离的哺乳动物心肌细胞、乳头肌制剂和射血心脏中，一氧化氮(NO)或其他循环GMP升高的干预措施通过加速心肌松弛的开始而增加舒张期细胞长度并降低峰值收缩性能。方法对13例无冠脉梗阻或其他心脏疾病的胸痛患者，在心导管置入术中于左室冠状动脉床注入NO供体硝普钠，观察NO对左心室舒张性和舒张性的影响。将硝普钠以小于或等于4微克/分钟的剂量注入冠状动脉内，该剂量以前被证明在向臂动脉注入时没有全身影响，以研究前臂血管床的反应性。冠脉内注射NO供体硝普钠的效果通过连续的左心室造影和尖端微压计的压力记录来评估。冠脉内注射硝普钠后心率由78+/-11次/min降至76+/-12次/min(P
Background In isolated mammalian cardiomyocytes, papillary muscle preparations, and ejecting hearts, nitric oxide (NO) or other cyclic GMP-elevating interventions increase diastolic cell length and reduce peak contractile performance by hastening onset of myocardial relaxation. In the present study, the effect of NO on left ventricular (LV) relaxation and diastolic distensibility was investigated in humans.Methods and Results The NO donor substance sodium nitroprusside was infused during cardiac catheterization in the global coronary bed of the LV of patients (n=13) investigated for chest pain who were without evidence of obstructive coronary artery or other cardiac disease. Sodium nitroprusside was infused intracoronarily at a dosage (less than or equal to 4 mu g/min) that was previously shown to be devoid of systemic effects when infused into the brachial artery to investigate the reactivity of the forearm vascular bed. The effect of this global intracoronary infusion of the NO donor sodium nitroprusside was assessed by sequential LV angiograms and tip-micromanometer pressure recordings. During global intracoronary nitroprusside infusion, there was a decrease in heart rate from 78+/-11 to 76+/-12 beats per minute (P