Neural markers of familial risk for depression: An investigation of cortical thickness abnormalities in healthy adolescent daughters of mothers with recurrent depression.
Neural markers of familial risk for depression: An investigation of cortical thickness abnormalities in healthy adolescent daughters of mothers with recurrent depression.
复制标题
DOI：
10.1037/abn0000050
复制
发表时间：
2015-08
影响因子：
4.6
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Foland-Ross LC;Gilbert BL;Joormann J;Gotlib IH
母亲患有重度抑郁症 (MDD) 是青春期末期和成年早期抑郁症的最强预测因素之一。尽管如此，我们对抑郁症风险代际传递的神经机制知之甚少。使用磁共振成像扫描了反复抑郁母亲（高风险）的 28 个从未失调的女儿和从未抑郁母亲（低风险）的 36 个从未失调的女儿。处理扫描数据以提供皮质灰质厚度的测量结果。在每个表面点进行一般线性模型，以评估家族风险对皮质结构的主要影响，并探讨家族风险与年龄的相互作用。与低风险女孩相比，高风险女孩的右侧梭状回皮质灰质明显更薄。探索性分析表明，双侧前岛叶和右前扣带皮层 (ACC) 的风险组和年龄之间存在相互作用；低风险女孩的年龄和皮质厚度呈负相关，而抑郁高风险女孩则表现出相反的模式。使用儿童悲伤管理量表的分数进行的其他探索性分析表明，高风险女孩的 ACC 灰质较薄，与管理悲伤的难度更大有关。这些发现表明，梭状回皮质厚度的异常减少可能是 MDD 风险的标志。年龄和群体对岛叶和 ACC 灰质厚度的相互作用表明这些区域在抑郁症风险中发挥着特别重要的作用，并需要进行更多的纵向研究。
Having a mother with Major Depressive Disorder (MDD) is one of the strongest predictors of depression in late adolescence and early adulthood. Despite this fact, we know little about the neural mechanisms involved in the intergenerational transmission of risk for depression. Twenty-eight never-disordered daughters of recurrent depressed mothers (high-risk) and 36 never-disordered daughters of never-depressed mothers (low-risk) were scanned using magnetic resonance imaging. Scan data were processed to provide measurements of cortical gray matter thickness. A General Linear Model was conducted at each surface point to assess the main effect of familial risk on cortical structure as well as to explore the interaction of familial risk and age. High-risk girls exhibited significantly thinner cortical gray matter in the right fusiform gyrus relative to low-risk girls. Exploratory analyses indicated interactions of risk group and age in the bilateral anterior insula and right anterior cingulate cortex (ACC); whereas low-risk girls exhibited an inverse association between age and cortical thickness, girls at high risk for depression showed the reverse pattern. Additional exploratory analyses, using scores on the Children’s Sadness Management Scale, indicated that thinner gray matter in the ACC of high-risk girls was associated with greater difficulty in managing sadness. These findings indicate that anomalous reductions in the cortical thickness of the fusiform gyrus may be a marker of risk for MDD. The interaction of age and group for gray matter thickness of the insula and ACC suggests a particularly important role for these regions in risk for depression and warrants additional research in longitudinal studies.