Aminoguanidine Prevents Impaired Healing and Deficient Angiogenesis in Diabetic Rats
Aminoguanidine Prevents Impaired Healing and Deficient Angiogenesis in Diabetic Rats
复制标题
DOI：
10.1023/a:1020246624605
复制
发表时间：
1999-12
期刊：
影响因子：
5.1
通讯作者：
A. S. Teixeira;M. Caliari;O. A. Rocha;R. D. Machado;S. P. Andrade
中科院分区：
文献类型：
--
作者：
A. S. Teixeira;M. Caliari;O. A. Rocha;R. D. Machado;S. P. Andrade
糖尿病生物体不能产生正常量的肉芽组织，这导致伤口愈合延迟，这是一个重要的临床问题。在本研究中，口服氨基胍（AG），在糖尿病诱导的血管生成和肉芽组织形成的抑制作用进行了测试。在非糖尿病大鼠皮下植入海绵盘可诱导伤口修复反应，这可通过植入物的血红蛋白量（血管指数）和肉芽组织形成（形态测定分析）来确定。在链脲佐菌素诱导的糖尿病大鼠中，指示愈合的主要反应是抑制性的。氨基胍是有效的，在50%的预防糖尿病诱导的抑制纤维血管组织生长的植入物，所示的血红蛋白含量和血管生长面积的植入物的值。这些结果表明，AG在糖尿病病情的愈合障碍的管理中具有潜在的治疗价值。
The diabetic organism is unable to produce normal amount of granulation tissue which results in delayed wound healing, a significant clinical problem. In the present study, the effect of oral administration of aminoguanidine (AG), in the diabetes-induced inhibition of angiogenesis and granulation tissue formation was tested. Subcutaneous implantation of sponge discs in nondiabetic rats induced a wound repair response as determined by the amount of hemoglobin (vascular index) and granulation tissue formation (morphometric analysis) of the implants. In the streptozotocin-induced diabetic rats the predominant response indicative of healing was inhibitory. Aminoguanidine was effective in preventing in 50% the diabetes-induced inhibition of fibrovascular tissue growth in the implants, as indicated by the values of hemoglobin content and vascular growth areas of the implants. These results indicate that AG holds potential therapeutic value in the management of healing impairment of the diabetic condition.