Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?
Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?
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淀粉样蛋白沉积是否会在认知正常的受试者中产生特定的萎缩特征？
DOI：
10.1016/j.nicl.2013.01.006
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
JackJr,CliffordR
中科院分区：
文献类型：
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作者：
Whitwell,JenniferL;Tosakulwong,Nirubol;Weigand,StephenD;Senjem,MatthewL;Lowe,ValJ;Gunter,JeffreyL;Boeve,BradleyF;Knopman,DavidS;Dickerson,BradfordC;Petersen,RonaldC;JackJr,CliffordR
本研究的目的是评估认知正常（CN）老年参与者显示皮质β-淀粉样蛋白（Aβ）沉积升高是否具有一致的脑萎缩神经解剖学特征，这可能是临床前阿尔茨海默病（AD）的特征。确定了115名通过淀粉样蛋白PET成像为Aβ阳性（CN +）的CN参与者; 115名Aβ阴性（CN-）的CN参与者;以及88名Aβ阳性轻度认知障碍或AD参与者（MCI/AD +）。测量了大脑28个感兴趣区域（ROI）的皮质厚度（FreeSurfer）和灰质体积（SPM 5），并进行了组间比较。最能区分CN −和CN +的ROI在FreeSurfer皮质厚度和SPM 5灰质体积方面存在差异。组明智的歧视是穷人与高度的不确定性方面的排名排序的ROI。相比之下，两种技术都显示出强有力的和一致的结果，将MCI/AD +与CN-和CN +组进行比较，内嗅皮层、中颞叶和下颞叶、下顶叶和海马为两种技术提供了最佳区分。与CN −与CN +比较相比，CN −和CN +与MCI/AD +比较的技术一致性更高。在本研究中，不同技术的结果的薄弱性和不一致性使人怀疑老年PiB阳性CN受试者中是否存在临床前AD的可靠神经解剖特征。
The objective of our study was to evaluate whether cognitively normal (CN) elderly participants showing elevated cortical beta-amyloid (Aβ) deposition have a consistent neuroanatomical signature of brain atrophy that may characterize preclinical Alzheimer's disease (AD). 115 CN participants who were Aβ-positive (CN +) by amyloid PET imaging; 115 CN participants who were Aβ-negative (CN −); and 88 Aβ-positive mild cognitive impairment or AD participants (MCI/AD +) were identified. Cortical thickness (FreeSurfer) and gray matter volume (SPM5) were measured for 28 regions-of-interest (ROIs) across the brain and compared across groups. ROIs that best discriminated CN − from CN + differed for FreeSurfer cortical thickness and SPM5 gray matter volume. Group-wise discrimination was poor with a high degree of uncertainty in terms of the rank ordering of ROIs. In contrast, both techniques showed strong and consistent findings comparing MCI/AD + to both CN − and CN + groups, with entorhinal cortex, middle and inferior temporal lobe, inferior parietal lobe, and hippocampus providing the best discrimination for both techniques. Concordance across techniques was higher for the CN − and CN + versus MCI/AD + comparisons, compared to the CN − versus CN + comparison. The weak and inconsistent nature of the findings across technique in this study cast doubt on the existence of a reliable neuroanatomical signature of preclinical AD in elderly PiB-positive CN participants.