Representativeness of a roster of volunteer North American twins with chronic disease.
Representativeness of a roster of volunteer North American twins with chronic disease.
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DOI：
10.1375/136905200320565670
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发表时间：
2000-03-01
期刊：
影响因子：
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通讯作者：
Hamilton, A S
中科院分区：
文献类型：
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作者：
Mack, T M;Deapen, D;Hamilton, A S
为了确定大量受慢性病影响的双胞胎作为研究环境和遗传慢性病决定因素的潜在对象，我们在1980年至1991年期间在北美的报纸上刊登广告，寻找受影响的双胞胎。从17245对双胞胎中收到了癌症或其他慢性疾病的反应。为了评估通过广告确定的受影响双胞胎的代表性，我们评估了报告模式，将确定的病例与估计在所有北美双胞胎中流行的病例数进行了比较，将病例与基于人群的单胞胎病例系列进行了比较，将健康的双胞胎与基于人群的健康人样本进行了比较，评估了对确定疾病原因的意见的影响，在最初未受影响的双胞胎病例中比较了前瞻性与回顾性疾病确定的模式，并将双胞胎中前瞻性疾病确定的结果与可比较的已发表估计值进行了比较。青年，性别，接合性，教育和疾病的一致性被认为是整体的确定的决定因素。疾病不一致的DZ双胞胎似乎是适度低估。虽然受教育程度稍高，但一致和不一致的双胞胎都被认为是受影响的非西班牙裔白色北美双胞胎的合理代表，他们的地位相当，即年龄、性别、种族和卵性相当。如果谨慎解释，这种双胞胎的一致性模式可以用来产生遗传假设，但不应该是确定的遗传力分析的基础。我们的结论是，广告提供了一种方法，确定对双胞胎，可以作为主题的研究，旨在确定疾病的决定因素。
To identify large numbers of twins affected by chronic disease as potential subjects for studies of environmental and genetic chronic disease determinants, we advertised for affected twins over the period 1980-91 in newspapers across North America. Responses were received from 17 245 twin pairs in which cases of cancer or other chronic disease had occurred. To assess the representativeness of affected twins identified by advertising, we evaluated the pattern of reporting, compared the cases identified to the number of cases estimated to be prevalent among all North American twins, compared the cases to population-based singleton case series, compared the healthy co-twins to population-based samples of healthy persons, assessed the impact on ascertainment of opinions about disease causation, compared the pattern of prospective to retrospective ascertainment of disease in the originally unaffected co-twins of cases, and compared the results of the prospective ascertainment of disease in co-twins to comparable published estimates. Youth, gender, zygosity, education, and disease concordance were found to be overall determinants of ascertainment. Disease-discordant DZ twins appeared to be modestly underascertained. While somewhat better educated, both concordant and discordant pairs were judged to be reasonably representative of affected non-Hispanic white North American twin pairs of comparable status, ie of comparable age, sex, race, and zygosity. If interpreted with caution, the concordance patterns of such twins can be used to generate genetic hypotheses, but should not be the basis of definitive heritability analyses. We conclude that advertising offers a method of identifying pairs of twins that can serve as subjects for studies designed to identify disease determinants.