Precision Public Health for the Era of Precision Medicine.
Precision Public Health for the Era of Precision Medicine.
复制标题
DOI：
10.1016/j.amepre.2015.08.031
复制
发表时间：
2016-03
影响因子：
5.5
通讯作者：
Riley WT
中科院分区：
文献类型：
--
作者：
Khoury MJ;Iademarco MF;Riley WT
精准医疗计划1承诺开创一个新的医疗保健时代。拟议的100万人队列可以更深入地了解疾病的原因。测序质量的提高、价格的降低以及“组学”领域和生物技术的进步预示着一个新时代，即个性化或精确医学。尽管基因组学是精准医疗的驱动力之一，但其他因素可能同样重要（例如，健康信息技术）。2.公共卫生专家对过度强调基因、药物和疾病，而忽视解决健康的社会决定因素的战略感到关切。公共卫生的一个主要关切是通过注重可改变的发病率和死亡率来促进健康、预防疾病和减少健康差距。2014年，疾病预防控制中心估计了美国每年由前五大原因造成的潜在可预防死亡人数3数据表明，至少三分之一的死亡是可以通过降低已知风险因素（例如吸烟，饮食不良和身体活动不足）的患病率来预防的。
The Precision Medicine Initiative1 promises a new healthcare era. A proposed 1 million—person cohort could create a deeper understanding of disease causation. Improvements in quality of sequencing, reduction in price, and advances in “omic” fields and biotechnology promise a new era, variably labeled personalized or precision medicine. Although genomics is one driver of precision health care, other factors may be as important (eg, health information technology).Both excitement and skepticism met the announcement. 2 Public health experts are concerned about the disproportionate emphasis on genes, drugs, and disease, while neglecting strategies to address social determinants of health. A prime concern for public health is promoting health, preventing disease, and reducing health disparities by focusing on modifiable morbidity and mortality. In 2014, CDC estimated the annual number of potentially preventable deaths from the top five causes in the US 3 Data suggest that at least one third of deaths are potentially preventable by reducing prevalence of known risk factors (eg, smoking, poor diet, and inadequate physical activity).