Projections of the pontine nuclei to the cochlear nucleus in rats
Projections of the pontine nuclei to the cochlear nucleus in rats
复制标题
大鼠脑桥核到耳蜗核的投射
DOI：
10.1002/cne.1068
复制
发表时间：
2001
影响因子：
2.5
通讯作者：
D. Ryugo
中科院分区：
文献类型：
--
作者：
Matthias Ohlrogge;J. Doucet;D. Ryugo
在耳蜗核中，存在神经元的大细胞核心，其轴突形成上行听觉通路。围绕着这个核心的是一层薄壳的微神经元，称为颗粒细胞结构域（GCD）。GCD接受听觉和非听觉输入，并依次投射到耳蜗背核，因此似乎是整合多感觉信息和下行反馈的中枢。然而，这些输入的来源和突触连接的性质相对未知。我们使用逆行示踪剂固蓝证明，一个主要的投影来自对侧脑桥核（PN）的GCD。投射细胞密集分布于PN的腹侧和吻侧。它们也被聚集成外侧和内侧组。将顺行示踪剂注入对侧GCD的PN标记苔藓纤维。终末局限于直接围绕耳蜗腹侧核的GCD部分。耳蜗背核无PN投射。光学显微镜和电子显微镜显示，这些纤维末端具有终扣和苔藓状纤维末端的形式。PN代表大脑和小脑皮质之间的关键站，因此脑桥耳蜗核投射成为引入听觉通路早期阶段的高度加工信息的重要来源。脑桥小脑通路可以给运动系统提供协调和时间线索。以类似的方式，也许脑桥耳蜗核投射赋予听觉系统提取时间信息的计时机制。J. Comp.神经元436：290-303，2001.© 2001 Wiley利斯公司
In the cochlear nucleus, there is a magnocellular core of neurons whose axons form the ascending auditory pathways. Surrounding this core is a thin shell of microneurons called the granule cell domain (GCD). The GCD receives auditory and nonauditory inputs and projects in turn to the dorsal cochlear nucleus, thus appearing to serve as a central locus for integrating polysensory information and descending feedback. Nevertheless, the source of many of these inputs and the nature of the synaptic connections are relatively unknown. We used the retrograde tracer Fast Blue to demonstrate that a major projection arises from the contralateral pontine nuclei (PN) to the GCD. The projecting cells are more densely located in the ventral and rostral parts of the PN. They also are clustered into a lateral and a medial group. Injections of anterograde tracers into the PN labeled mossy fibers in the contralateral GCD. The terminals are confined to those parts of the GCD immediately surrounding the ventral cochlear nucleus. There is no PN projection to the dorsal cochlear nucleus. These endings have the form of bouton and mossy fiber endings as revealed by light and electron microscopy. The PN represent a key station between the cerebral and cerebellar cortices, so the pontocochlear nucleus projection emerges as a significant source of highly processed information that is introduced into the early stages of the auditory pathway. The cerebropontocerebellar pathway may impart coordination and timing cues to the motor system. In an analogous way, perhaps the cerebropontocochlear nucleus projection endows the auditory system with a timing mechanism for extracting temporal information. J. Comp. Neurol. 436:290–303, 2001. © 2001 Wiley‐Liss, Inc.
对耳蜗背核神经元的体感影响。
DOI：
10.1152/jn.1995.73.2.743
发表时间：
1995
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
Young,ED;Nelken,I;Conley,RA
通讯作者：
Conley,RA