Simple Quantitative Indices for the Differentiation of Advanced-Stage Alzheimer's Disease and Other Limbic Tauopathies.
Simple Quantitative Indices for the Differentiation of Advanced-Stage Alzheimer's Disease and Other Limbic Tauopathies.
复制标题
区分晚期阿尔茨海默病和其他边缘 Tau蛋白病的简单定量指数。
DOI：
10.3233/jad-210043
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Y. Hashizume
中科院分区：
文献类型：
--
作者：
K. Sakurai;D. Kaneda;S. Inui;Yuto Uchida;S. Morimoto;T. Nihashi;Takashi Kato;Kengo Ito;Y. Hashizume
背景
阿尔茨海默病（AD）与年龄相关性边缘系统tau蛋白病（LT）（包括嗜银颗粒病（AGD）和神经元缠结型老年性痴呆（SD-NFT））的鉴别常常是具有挑战性的，因为尚未建立具体的临床诊断标准。尽管评估淀粉样蛋白和tau蛋白的特异性生物标志物可用于检测AD相关的病理生理学变化，但其费用和相关的侵入性使其无法用作所有痴呆患者的一线诊断工具。因此，低侵入性和昂贵的生物标志物将是有价值的，在常规临床实践中的AD和LT的区分。
目的
本研究的目的是开发一种简单的可重复的磁共振成像（MRI）方法，可用于日常临床实践中区分AD和其他形式的LT。
方法
我们新提出的三个定量指标和众所周知的内侧颞叶萎缩（MTA）评分使用MRI的病理证实的晚期AD 21，AGD 10，和2 SD-NFT患者进行了评估。
结果
与MTA评分相反，海马角（HPA）、下角面积（IHA）以及HPA和IHA之间的比值（即，IHPA指数）表现出更高的诊断性能和可重复性，特别是区分晚期AD患者Braak神经系统缠结V/VI期与LT患者（受试者工作特征曲线下面积分别为0.83，089和0.91;组内相关系数分别为0.930，0.998和0.995）。
结论
反映海马变形伴脑室扩大的定量指标有助于鉴别晚期AD和LT。这种简便的方法可用于日常临床实践。
BACKGROUND
The differentiation of Alzheimer's disease (AD) from age-related limbic tauopathies (LT), including argyrophilic grain disease (AGD) and senile dementia of the neurofibrillary tangle type (SD-NFT), is often challenging because specific clinical diagnostic criteria have not yet been established. Despite the utility of specific biomarkers evaluating amyloid and tau to detect the AD-related pathophysiological changes, the expense and associated invasiveness preclude their use as first-line diagnostic tools for all demented patients. Therefore, less invasive and costly biomarkers would be valuable in routine clinical practice for the differentiation of AD and LT.
OBJECTIVE
The purpose of this study is to develop a simple reproducible method on magnetic resonance imaging (MRI) that could be adopted in daily clinical practice for the differentiation of AD and other forms of LT.
METHODS
Our newly proposed three quantitative indices and well-known medial temporal atrophy (MTA) score were evaluated using MRI of pathologically-proven advanced-stage 21 AD, 10 AGD, and 2 SD-NFT patients.
RESULTS
Contrary to MTA score, hippocampal angle (HPA), inferior horn area (IHA), and ratio between HPA and IHA (i.e., IHPA index) demonstrated higher diagnostic performance and reproducibility, especially to differentiate advanced-stage AD patients with Braak neurofibrillary tangle stage V/VI from LT patients (the area under the receiver-operating-characteristic curve of 0.83, 089, and 0.91; intraclass correlation coefficients of 0.930, 0.998, and 0.995, respectively).
CONCLUSION
Quantitative indices reflecting hippocampal deformation with ventricular enlargement are useful to differentiate advanced-stage AD from LT. This simple and convenient method could be useful in daily clinical practice.
影响因子：
11
作者：
Matsui, Y.;Tanizaki, Y.;Kiyohara, Y.
通讯作者：
Kiyohara, Y.