The Arabidopsis thaliana Nuclear Factor Y Transcription Factors.
The Arabidopsis thaliana Nuclear Factor Y Transcription Factors.
复制标题
拟南芥核因子 Y 转录因子
DOI：
10.3389/fpls.2016.02045
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发表时间：
2016
影响因子：
5.6
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
Zhao H;Wu D;Kong F;Lin K;Zhang H;Li G
核因子Y（NF-Y）是一种进化上保守的三聚体转录因子复合体，存在于几乎所有的真核生物中。异源三聚体NF-Y复合物由NF-YA、NF-YB和NF-YC三个亚基组成，并结合其靶基因启动子区的CCAAT盒以调节其表达。酵母和哺乳动物基因组通常具有编码每个NF-Y亚基的具有多个剪接同种型的单个基因。相比之下，植物基因组通常具有编码每个亚基的多基因家族，并且这些基因在不同组织或阶段中差异表达。因此，不同的亚基组合可以在不同的组织、阶段和生长条件下产生各种各样的NF-Y复合物，这表明该复合物在植物中具有潜在的多样性功能。事实上，最近的许多研究已经证明，NF-Y复合物在植物生长，发育和胁迫反应中起着多种重要作用。本文就NF-Y在拟南芥中的研究进展作一综述，包括NF-Y蛋白的结构、异源三聚体复合物的形成以及NF-Y调控下游靶基因表达的分子机制。然后，我们专注于它的生物学功能和潜在的分子机制。最后，对NF-Y的未来研究方向进行了展望。
Nuclear factor Y (NF-Y) is an evolutionarily conserved trimeric transcription factor complex present in nearly all eukaryotes. The heterotrimeric NF-Y complex consists of three subunits, NF-YA, NF-YB, and NF-YC, and binds to the CCAAT box in the promoter regions of its target genes to regulate their expression. Yeast and mammal genomes generally have single genes with multiple splicing isoforms that encode each NF-Y subunit. By contrast, plant genomes generally have multi-gene families encoding each subunit and these genes are differentially expressed in various tissues or stages. Therefore, different subunit combinations can lead to a wide variety of NF-Y complexes in various tissues, stages, and growth conditions, indicating the potentially diverse functions of this complex in plants. Indeed, many recent studies have proved that the NF-Y complex plays multiple essential roles in plant growth, development, and stress responses. In this review, we highlight recent progress on NF-Y in Arabidopsis thaliana, including NF-Y protein structure, heterotrimeric complex formation, and the molecular mechanism by which NF-Y regulates downstream target gene expression. We then focus on its biological functions and underlying molecular mechanisms. Finally, possible directions for future research on NF-Y are also presented.