Hexylitaconic acid:: A new inhibitor of p53-HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp.
Hexylitaconic acid:: A new inhibitor of p53-HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp.
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DOI：
10.1016/j.bmcl.2005.09.052
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发表时间：
2006-01-01
影响因子：
2.7
通讯作者：
Yokosawa, H
中科院分区：
文献类型：
--
作者：
Tsukamoto, S;Yoshida, T;Yokosawa, H
从海洋真菌Arthines sp.的培养中分离到一种新的P53-Hdm2相互作用的抑制物。经波谱分析，确定其结构为(-)-己糖酸(1)。用ELISA法检测对P53-Hdm2结合的抑制作用，1抑制P53-Hdm2的结合，IC50值为50mUg/mL。虽然到目前为止已经报道了一些合成的P53-Hdm2相互作用的抑制剂，但1是第二个从自然资源中分离出来的抑制剂。(C)2005爱思唯尔有限公司。保留所有权利。
A new inhibitor of p53-HDM2 interaction was isolated from a culture of marine-derived fungus, Arthrinium sp. The structure was identified to be (-)-hexylitaconic acid (1) by spectroscopic analysis. The inhibition of p53-HDM2 binding was tested by the ELISA method, and 1 inhibited the binding with an IC50 value of 50 mu g/mL. Although a number of synthetic inhibitors of p53-HDM2 interaction have been reported so far, 1 is the second inhibitor isolated from natural resources. (c) 2005 Elsevier Ltd. All rights reserved.