The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. A quantitative histologic study.
The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. A quantitative histologic study.
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中等厚度（0.76-4.0毫米厚）皮肤黑色素瘤中肿瘤血管分布的预后意义。
DOI：
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发表时间：
1988
影响因子：
6
通讯作者：
L. Hughes
中科院分区：
文献类型：
--
作者：
P. Laidler;P. Rosalind;Davies;K. Horgan;L. Hughes
对20例原发性皮肤黑色素瘤的血管性进行组织学评价。这些病例是从手术治疗的中厚度黑色素瘤（0.76-4.0 mm厚）患者中选择的，分为两组，每组10例。一组患者随访至少9年，无复发迹象。第二组10名患者在随访中出现局部或全身转移，其中7名患者死于播散性黑色素瘤。两组患者的年龄、性别、布雷斯洛肿瘤的厚度和克拉克的浸润程度相似。用Ulex europaeus-I凝集素染色确定血管后，通过图像分析进行血管定量。复发组肿瘤底部血管面积百分比是无复发组的2倍以上。本研究提示肿瘤基部血管的增加可能对中厚黑色素瘤的预后有重要意义。
The vascularity of 20 primary skin melanomas was assessed histologically. These cases were selected from patients with intermediate thickness melanomas (0.76-4.0 mm thick) treated surgically to provide two groups of ten patients. One group had no evidence of recurrence with a minimum follow-up of 9 years. The second group of ten patients developed locoregional or systemic metastasis under follow-up, and seven of these patients died of disseminated melanoma. Age, sex, Breslow's tumor thickness, and Clark's level of invasion were similar in the two groups. Vascular quantitation was carried out by image analysis after vascular definition by Ulex europaeus-I agglutinin staining. The percentage vascular area at the tumor base in the recurrence group was more than twice that in the recurrence-free group. This study suggests that increased vascularity at the tumor base may have prognostic significance in intermediate thickness melanomas.