Identification of metabolism-associated pathways and genes involved in male and female liver cancer patients
Identification of metabolism-associated pathways and genes involved in male and female liver cancer patients
复制标题
男性和女性肝癌患者代谢相关途径和基因的鉴定
DOI：
10.1016/j.jtbi.2019.08.011
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Lin Wang
中科院分区：
文献类型：
--
作者：
Ren-Chao Zou;Shufeng Xiao;Zhitian Shi;Ke Yang;Haoran Tang;Tiangen Wu;Zhitang Guo;Fan Ni;Wen-Xing Li;Lin Wang
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer. HCC is influenced by sex and multiple metabolic abnormalities. The present study aimed to compare the overall metabolic changes between male and female HCC patients and identify key metabolic genes. Metabolic genes and pathways were identified based on analyses of publicly available data. Differential expression analysis, gene set enrichment analysis, survival analysis and transcriptional regulation analysis were employed to explore sex differences and identify key metabolic genes in HCC. The results suggested that female patients had more severe metabolic gene expression abnormalities and pathway deregulation than male patients. This study identified 9 key metabolic genes, and only upregulated ALDH1A2 independently increased overall survival risk in patients. Bioinformatic analyses suggest that upregulated GATA3 and TAL1 activate ALDH1A2 and then disrupt amino acid and carbohydrate metabolism, which may increase the risk of HCC. This study identified a novel contribution of upregulated ALDH1A2 to HCC. Future studies are needed to elucidate the potential metabolic mechanism of the role of ALDH1A2 in HCC.
