Hydration of phosphorylcholine groups attached to highly swollen polymer hydrogels studied by thermal analysis
Hydration of phosphorylcholine groups attached to highly swollen polymer hydrogels studied by thermal analysis
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DOI：
10.1016/j.polymer.2008.08.025
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发表时间：
2008-10
期刊：
影响因子：
4.6
通讯作者：
Toshinori Morisaku;J. Watanabe;T. Konno;M. Takai;K. Ishihara
中科院分区：
文献类型：
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作者：
Toshinori Morisaku;J. Watanabe;T. Konno;M. Takai;K. Ishihara
聚合物链的水合作用对于确定蛋白质在聚合物材料上的吸附程度起着关键作用。在这里，我们研究了聚（2-甲基丙烯酰氧乙基磷酰胆碱（MPC））链的水化，它可以有效地抵抗蛋白质吸附和细胞粘附。将水合作用与也具有亲水单元的聚（甲氧基低聚（乙二醇）-单甲基丙烯酸酯（Me（EG）nMA））链的水合作用进行了比较。制备了平衡水含量（EWC）在86 ~ 97wt%范围内的聚（MPC）和聚（Me（EG）nMA）水凝胶。通过差示扫描量热法测量，水凝胶中的水分为两种状态：可冻结和不可冻结的水。在EWC相近的情况下，聚MPC水凝胶的不冻水比聚Me（EG）nMA水凝胶的不冻水大，说明聚MPC链具有更强的水化能力。我们认为，在高分子链周围的非冻结水的量的差异可能会影响蛋白质吸附阻力的程度后，长期接触体液。
Hydration of polymer chains plays a key role for determining the extent of protein adsorption on polymeric materials. Here we investigated the hydration of poly(2-methacryloyloxyethyl phosphorylcholine (MPC)) chains, which resist protein adsorption and following cell adhesion effectively. The hydration was compared with that of poly(methoxy oligo(ethylene glycol)-monomethacrylate (Me(EG)nMA)) chains, which also have hydrophilic units. The poly(MPC) and poly(Me(EG)nMA) hydrogels with equilibrium water contents (EWCs) in the range from 86 to 97wt% were prepared. By differential scanning calorimetric measurements, water in both the hydrogels was classified into two states: freezable and nonfreezable water. The poly(MPC) hydrogels had larger nonfreezable water than the poly(Me(EG)nMA) hydrogels even when their EWCs were similar, which indicated the higher hydrating ability of poly(MPC) chains. We suggested that the difference in the amount of nonfreezable water around polymer chains may influence the degree of protein adsorption resistance after contact with body fluid for a long period.